Systemic Lupus Erythematosus (SLE)
Conditions
Keywords
lupus, echocardiography
Brief summary
To investigate biomarkers to identify pediatric SR-SLE patients by non-invasive echocardiographic techniques.
Detailed description
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease. Although therapeutic advances have improved outcomes, a significant subset remains with severe disease activity despite optimal therapy, which is recognized as the severe refractory SLE (SR-SLE).A recent study using advanced echocardiographic techniques of global longitudinal strain (GLS) have revealed that left ventricular dysfunction is common in SLE patients and correlates with disease severity.The finding underscores the potential role of early myocardial dysfunction as a phenotypic marker of SR-SLE.To our knowledge, there are no validated biomarkers to reliably identify patients with SR-SLE at an early stage, especially in the pediatric population. Therefore, this study aimed to investigate biomarkers to identify pediatric SR-SLE patients.
Interventions
None listed
Sponsors
Shanghai Jiao Tong University School of Medicine
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
7 Years to 17 Years
Healthy volunteers
Yes
Inclusion criteria
* fulfill the American College of Rheumatology (ACR) criteria * disease onset at ages before 18 years
Exclusion criteria
* patients with a history of concomitant malignancy * patients with active bacterial, viral, fungal, mycobacterial infection
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| echocardiographic measurements | 6 months | echocardiographic measurements including chamber dimensions, LV systolic and diastolic function, valve disease, strain values and etc.. |
Countries
China
Contacts
PRINCIPAL_INVESTIGATORBao
Shanghai Children's Medical Center, Shanghai Jiaotong University School of Medicine
Outcome results
None listed