Optic Nerve Head Strain in Non-glaucoma Subjects

Status

Recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07425535

Enrollment

Registered

2026-02-23

Start date

2026-06-24

Completion date

2028-03-31

Last updated

2026-07-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Glaucoma

Keywords

optic nerve, biomechanical strain, normal eye, glaucoma

Brief summary

Persons who do not have glaucoma will have pictures taken of the optic nerve with a standard camera before and 2 weeks after starting to take a daily glaucoma eye drop to lower eye pressure. These data will be used to compare to the same procedure performed with glaucoma patients to study how glaucoma injures the eye.

Detailed description

The present proposal seeks to measure biomechanical strains in age-matched control subjects who do not have Open-angle Glaucoma (OAG), using the same non-invasive imaging methods as in the above programs. This is necessary as even undamaged OAG eyes may have different biomechanical properties at baseline than do non-OAG eyes. While there are some limited methods to test strains in control eyes, to compare normal to OAG responses robustly, the same methods of changing intra-ocular pressure (IOP) must be applied-namely to lower IOP by delivery of FDA-approved agent, latanoprost, as has been done in the investigator's OAG subjects. The method of measuring strain requires images taken at two different IOP levels.

Interventions

DRUGLatanoprost (0.005%)

Participants take the eye drop daily for less than one month

Study design

Allocation

Intervention model

SINGLE_GROUP

Primary purpose

DIAGNOSTIC

Masking

NONE

Masking description

Biostatistician

Eligibility

Sex/Gender

ALL

Age

30 Years to 90 Years

Healthy volunteers

Yes

Inclusion criteria

* Adults who have no history of OAG * Have an ocular examination by a glaucoma specialist with no indications of OAG * Have normal optical coherence tomography findings in the retinal nerve fiber layer. * Over age 30 will be included from * Both sexes * All ethnic groups. * Optic neuropathy. * Both suspects and those with glaucoma damage will be included. * When both eyes meet inclusion and

Exclusion criteria

, both eyes will be included in the study and statistical methods will be used to account for correlations between eyes within the same individual.

Design outcomes

Primary

Measure	Time frame	Description
Optic nerve head strain	up to 1 month	Biomechanical strain measured by optical coherence tomography

Countries

United States

Contacts

CONTACTHarry A Quigley, MD

hquigley@jhmi.edu410 955 6051

CONTACTFarzaneh Dadvar, MD

fdadvar1@jh.edu

PRINCIPAL_INVESTIGATORHarry Quigley, MD

Johns Hopkins University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jul 14, 2026