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Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training in Sedentary Women

Contralateral Effects of Unilateral Isokinetic vs. Single-Leg Squat Training on Strength, Proprioception, and Muscle Thickness in Sedentary Women: A Randomized Controlled Trial

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07425288
Enrollment
47
Registered
2026-02-20
Start date
2023-11-15
Completion date
2024-05-22
Last updated
2026-02-20

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Muscle Strength, Proprioception

Keywords

contralateral training, isokinetic training, single-leg squat, proprioception.

Brief summary

This randomized controlled trial aims to investigate the contralateral effects of unilateral training in sedentary women. Specifically, the study compares unilateral isokinetic training and single-leg squat training to determine their effects on strength, proprioception, and muscle thickness in both the trained and untrained lower extremities. Participants will be randomly assigned to one of the training groups. The intervention will be applied to one lower limb only. Strength, proprioception, and muscle thickness will be assessed before and after the intervention period. The primary objective is to evaluate whether unilateral training induces cross-education effects in the contralateral limb. The findings of this study may contribute to rehabilitation strategies by clarifying the potential benefits of unilateral exercise programs for improving neuromuscular performance and muscle morphology in sedentary individuals.

Interventions

BEHAVIORALUnilateral Isokinetic Training

Unilateral isokinetic strength training will be applied to one lower extremity using an isokinetic dynamometer. The training program will be performed according to the study protocol. The contralateral limb will not receive any direct intervention.

BEHAVIORALUnilateral Single-Leg Squat Training

Participants will perform unilateral single-leg squat exercises on one lower extremity according to the study protocol. The opposite limb will not receive any direct training.

Sponsors

Cagatay Muslum Gokdogan
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
SINGLE (Outcomes Assessor)

Intervention model description

Participants will be randomly assigned to one of three parallel groups. Two experimental groups will receive unilateral exercise interventions, consisting of unilateral isokinetic training or unilateral single-leg squat training. A third group will serve as a control group and will not receive any intervention. Participants will remain in their assigned groups throughout the study period.

Eligibility

Sex/Gender
FEMALE
Age
18 Years to 35 Years
Healthy volunteers
Yes

Inclusion criteria

* female gender, * no lower extremity problems in the last 6 months, * not actively participating in sports

Exclusion criteria

* history of orthopedic surgery within the last 2 years, * ongoing lower extremity pain, systemic disease that could prevent exercise, * a neurological problems.

Design outcomes

Primary

MeasureTime frameDescription
Muscle StrengthBaseline and after 6 weeks of interventionMuscle strength of the lower extremities will be assessed using isokinetic dynamometry to evaluate peak torque values in both the trained and contralateral limbs.

Secondary

MeasureTime frameDescription
ProprioceptionBaseline and after 6 weeks of interventionLower extremity proprioception will be evaluated using joint position sense assessment to determine proprioceptive accuracy in both limbs.
Muscle ThicknessBaseline and after 6 weeks of interventionMuscle thickness of selected thigh muscles will be measured using ultrasonography to assess morphological adaptations following unilateral training.

Countries

Turkey (Türkiye)

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 21, 2026