The Effect of Exercise-Induced Irisin on Brain Function and Postoperative Delirium in Older Adults

Association of the Exercise-Irisin-EEG Cascade With Intrinsic Brain Vulnerability and Its Impact on Postoperative Delirium in Elderly Patients: A Prospective Cohort Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07424170

Enrollment

140

Registered

2026-02-20

Start date

2026-07-01

Completion date

2027-06-30

Last updated

2026-09-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post Operative Delirium

Keywords

exercise, irisin, Post Operative Delirium

Brief summary

The goal of this observational study is to learn how exercise-induced irisin protects the brain. It also explores irisin's effect on postoperative delirium (POD) in older adults. The main questions it aims to answer are: Does daily activity link to POD? Does irisin play a mediating role in this process? Researchers will enroll active and inactive adults aged 65 and older. All will have surgery under spinal anesthesia. The researchers will measure irisin levels in spinal fluid. They will track POD and other complications for five days after surgery.

Interventions

BEHAVIORALPreoperative physical activity level

Before the surgery, the activity levels of the participants over the past week were assessed using the Physical Activity Scale for the Elderly (PASE).

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

65 Years to No maximum

Healthy volunteers

Yes

Inclusion criteria

* Aged ≥ 65 years; * Classified as ASA physical status I to III; * Scheduled for non-cardiovascular surgery under spinal anesthesia or combined spinal-epidural anesthesia; * Expected surgical duration of at least 2 hours; * Voluntarily provide written informed consent and agree to participate in this study.

Exclusion criteria

* Significant change in exercise status within the past 7 days due to injury or other reasons; * Contraindications to neuraxial anesthesia; * Unable to assess cognitive function or Montreal Cognitive Assessment (MoCA) score \< 23; * Preoperative diagnosis of delirium; * History of traumatic brain injury or neurosurgery; * Long-term opioid use or history of alcohol abuse; * Planned surgery cancelled or changed (including intraoperative events that significantly alter the procedure or duration); * Change in anesthesia method.

Design outcomes

Primary

Measure	Time frame	Description
Postoperative Delirium	five days after surgery	Delirium will be assessed using the CAM or CAM-ICU (for patients in the ICU) by researchers twice daily. For patients who develop POD, the severity of POD will be evaluated using the Delirium Rating Scale-Revised-98 (DRS-R-98).

Countries

China

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 11, 2026