Asymptomatic Apical Periodontitis
Conditions
Keywords
Asymptomatic Apical Periodontitis, pectin, bio-c temp, Calcium Hydroxide
Brief summary
It is tackling antimicrobial resistance in endodontics, specifically comparing different intracanal medications used in root canal treatment. Given the growing concern over resistant bacterial strains, our study aims to evaluate the effectiveness of various medicaments in eliminating endodontic pathogens while minimising the risk of resistance development. By integrating microbiological analysis and clinical relevance, our research seeks to provide evidence-based recommendations for optimising intracanal disinfection protocols and improving treatment outcomes in endodontic infections.
Interventions
Patients receiving CaOH (Metapaste) intracanal medication
DRUGCalcium silicate based intracanal medication
Patients receiving Calcium silicate based (Bio-C Temp) intracanal medication
DRUGPectin
Patients receiving Pectin intracanal medication
Sponsors
Suez Canal University
University of Leeds
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
QUADRUPLE (Subject, Caregiver, Investigator, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
21 Years to 49 Years
Healthy volunteers
Yes
Inclusion criteria
* Patients presenting with a single rooted mandibular premolar tooth with a closed apex and a single patent canal type I in Vertucci's classification (Vertucci et al., 1974). * Having a necrotic pulp. * A pocket depth measurement of \< 3 mm. * Teeth with no previous history of endodontic treatment. * Teeth with periapical lesions of endodontic origin having a periapical index score of 4 or 5 (Orstavik et al., 1986) * Patients who took antibiotics within the period of three months before the study. * Non-restorable teeth. * Teeth with periodontal pockets deeper than 4mm, with or without concomitant or combined endo-perio communication * Multirooted teeth. * Previously initiated or treated teeth. * Teeth with root canal calcifications or resorption. * Teeth with internal/external root resorption or root fracture. * Immune-compromised patients or patients with systemic diseases i.e. (diabetes mellitus, human immunodeficiency virus, leukemia, neutropenia, undergoing chemo- or systemic corticosteroid therapy) * Teeth with root curvature of more than 15 degrees. * Pregnant women * Patients with known sensitivity to the medicaments used in this study.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Microbiome Changes | From enrollment to the end of treatment at 2 weeks | Compare the changes in the microbial composition of the biofilm inside the infected root canal before and after chemo-mechanical preparation and before and after intracanal medicaments application using DNA next-generation sequencing. |
Countries
Egypt
Contacts
PRINCIPAL_INVESTIGATOROmar Montaser, M.D.Sc
Suez Canal University
Outcome results
None listed