Chronic Intestinal Failure, Intestinal Failure, Home Parenteral Nutrition
Conditions
Keywords
Parenteral Nutrition, Intravenous Amino Acids
Brief summary
The purpose of this study is to gain insight into the actual protein requirements of patients with chronic intestinal failure (CIF) receiving home parenteral nutrition, which could improve clinical management of these patients. Based on collected data on protein kinetics, the study aims to further refine and personalize nutritional mixtures in patients with CIF. Additional aims include assessment of short-chain fatty acid metabolism and evaluation of gut microbiota function in patients with CIF.
Detailed description
This prospective cohort study evaluates anabolic response to intravenous amino acid administration and metabolic phenotype in patients with chronic intestinal failure (CIF) receiving home parenteral nutrition. The study aims to improve therapy of CIF patients by providing new insights into metabolism and anabolic response. Protein kinetics will be assessed to better define protein requirements and to support optimization and personalization of parenteral nutrition mixtures. The study will also assess short-chain fatty acid metabolism and provide insight into gut microbiota function in CIF patients.
Interventions
Intravenous amino acid administration to assess anabolic response and protein kinetics in patients with chronic intestinal failure receiving home parenteral nutrition
Sponsors
Institute of Oncology Ljubljana
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE
Intervention model description
Single-group study assessing anabolic response to intravenous amino acid administration and metabolic phenotype in patients with chronic intestinal failure receiving home parenteral nutrition.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
\- Patients with chronic intestinal failure (CIF) receiving home parenteral nutrition.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Whole-Body Protein Kinetics (Protein Synthesis Rate) After Intravenous Amino Acid Infusion | Baseline (prior to amino acid infusion) and immediately after amino acid infusion (within 1 day) | Protein anabolic response will be assessed by whole-body protein kinetics using a stable isotope tracer methodology during intravenous amino acid administration. The outcome will be reported as the change in whole-body protein synthesis rate (µmol/kg/h) from baseline to post-infusion. |
Countries
Slovenia
Contacts
CONTACTKlavdija Korošec
CONTACTNeža Gros
Outcome results
None listed