Stroke
Conditions
Keywords
Acute ischemic stroke, Alteplase, Tenecteplase, Stroke at 4.5 to 24 Hours
Brief summary
A multicenter, retrospective, observational cohort study on intravenous thrombolysis beyond the time window for acute ischemic stroke
Interventions
None listed
Sponsors
Xuanwu Hospital, Beijing
Study design
Observational model
COHORT
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Patients with acute ischemic stroke, regardless of gender; 2. Age ≥ 18 years old; 3. Time from onset to treatment within 4.5 - 24 hours (the onset time refers to the last time when they appeared normal); 4. Complete relevant clinical data (including gender, age, mRS, NIHSS, etc.).
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Proportion of study participants with mRS scores of 0 - 1 | at 90 (±7) days | Proportion of study participants with mRS scores of 0 - 1 |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Distribution of mRS scores ranging from 0 to 6 | at 90 (±7) days | Distribution of mRS scores ranging from 0 to 6 |
| Proportion of study participants with mRS scores of 0 - 2 | at 90 (±7) days | Proportion of study participants with mRS scores of 0 - 2 |
| The proportion of study participants with a NIHSS score of ≤1 or a decrease of ≥8 points compared to the baseline | at 24 (±12) hours | The proportion of study participants with a NIHSS score of ≤1 or a decrease of ≥8 points compared to the baseline |
| mortality rate | at 90 (±7) days | mortality rate |
| Symptomatic intracranial hemorrhage | within 36 hours | Symptomatic intracranial hemorrhage |
Countries
China
Contacts
CONTACTXin Xing, MD
Outcome results
None listed