Neurogenic Lower Urinary Tract Dysfunction, Spinal Cord Injury
Conditions
Keywords
Spinal Cord Injury, Neurogenic lower urinary tract dysfunction, Bladder wall thickness, Urodynamic studies, Ultrasonography
Brief summary
This study aims to investigate the correlation between detrusor and bladder wall thickness measured by suprapubic ultrasound and urodynamic parameters in patients with spinal cord injury. By evaluating ultrasonographic measurements alongside urodynamic findings, the study seeks to assess their relationship in a prospective cross-sectional setting.
Detailed description
This single-center, prospective cross-sectional observational study was conducted to evaluate the association between detrusor and bladder wall thickness measured by suprapubic ultrasound and urodynamic parameters in patients with spinal cord injury. Patients with spinal cord injury were prospectively enrolled and underwent suprapubic ultrasonography and urodynamic evaluation as part of the study protocol. Detrusor wall thickness and bladder wall thickness were measured using suprapubic ultrasonography according to a standardized protocol. Urodynamic parameters, including detrusor pressure and other relevant measurements, were recorded during routine urodynamic assessment. The relationship between ultrasonographic measurements and urodynamic findings was analyzed to assess their correlation.
Interventions
None listed
Sponsors
Ankara City Hospital Bilkent
Study design
Observational model
OTHER
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
1. ≥18-65 years of age 2. Traumatic and non-traumatic SCI 3. Willingness to participate and able to provide written informed consent
Exclusion criteria
1. Neurogenic lower urinary tract dysfunction not caused by spinal cord injury 2. History of brain surgery 3. History of augmentative urinary surgery or invasive bladder procedures (e.g., bladder tumor resection, botulinum toxin injection) 4. History of urinary tract malignancy 5. Prior overactive bladder or urinary incontinence, or prior surgery for benign prostatic hyperplasia 6. Bladder outlet obstruction 7. Cognitive impairment that would interfere with participation 8. Active urinary tract infection preventing urodynamic evaluation
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Correlation between ultrasound-measured detrusor and bladder wall thickness and urodynamic parameters | Ultrasonographic measurements were performed during the same clinical evaluation period, either on the same day as or within one day prior to the urodynamic study. | The association between suprapubic ultrasound-measured bladder wall thickness and detrusor wall thickness and urodynamic parameters, including cystometric capacity, maximum cystometric capacity, maximum detrusor pressure, leak point pressure, bladder capacity at the time of leakage, total leakage volume, bladder compliance, presence of bladder sensation, presence of detrusor overactivity, presence of sphincter hyperactivity, maximum flow rate, detrusor pressure at maximum flow, voided volume, and postvoid residual urine volume. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Association of bladder and detrusor wall thickness with clinical characteristics | During the same clinical evaluation period as the urodynamic study, either on the same day as or one day prior to urodynamic testing. | The association between suprapubic ultrasound-measured bladder wall thickness and detrusor wall thickness (measured in millimeters, mm) and clinical characteristics, including sex (male/female), neurological level of injury, distribution of paralysis (paraplegia/tetraplegia), injury severity according to the ASIA Impairment Scale (AIS A-E), duration since injury (months), etiology of spinal cord injury, bladder emptying method, use of anticholinergic medication (yes/no), presence of pressure ulcers (yes/no), and history of recurrent urinary tract infections (yes/no). |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORHakan Tunç, Professor doctor
Ankara City Hospital Bilkent
Outcome results
None listed