Obsessive-Compulsive Disorder (OCD)
Conditions
Brief summary
This study tests out procedures to look at whether a type of brain stimulation called transcranial magnetic stimulation impacts flexible shifts in behavior in obsessive-compulsive disorder (OCD). This study examines whether study procedures are feasible and acceptable to people participating in the study, but does not determine whether this type of brain stimulation causes changes.
Interventions
DEVICEcontinuous theta-burst transcranial magnetic stimulation (cTBS)
3 consecutive daily sessions of cTBS
Sponsors
Dartmouth-Hitchcock Medical Center
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
OTHER
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to 60 Years
Healthy volunteers
Yes
Inclusion criteria
* Current primary DSM-5 OCD diagnosis and current Y-BOCS total score of ≥16 (OCD group, only) or no current diagnosis of an emotional disorder, and no known history of OCD, PTSD, anxiety disorder(s), or recurrent major depressive disorder (Healthy participant group, only) * 18-60 years of age * ability to speak, read, write, and understand English sufficiently well to complete study procedures and provide informed consent * psychotherapy and/or psychiatric medication use remain stable for 6 weeks prior to study entry
Exclusion criteria
* Presence of current psychiatric diagnosis (healthy control group, only) * active substance use disorder * history of mania or hypomania, or lifetime presence of significant psychotic symptoms * active suicidal or homicidal ideation * use of medications known to reduce seizure threshold (e.g., stimulants) * organic brain disease or injury representing a contraindication to TMS * any health problems that would interfere with safe and/or practical study participation, including contraindications to TMS (e.g., seizure disorder, presence of metal hardware that would come in close contact with the discharging coil) * current pregnancy or planning to become pregnant during the study period
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Rate of enrollment | At study enrollment | Percent of screened participants who are determined to be eligible and enrolled. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Rates of visit completion | From enrollment to date of post-TMS study visit (approximately 1 week) | Percent (%) of enrolled participants completing each study visit |
| Peak cTBS intensity tolerated | From enrollment to end of TMS sessions (approximately 1 week) | Average of peak intensity (up to target intensity) tolerated during cTBS sessions |
Outcome results
None listed