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Personalised Process-based Psychological Interventions for Paediatric Headaches

Personalised Process-based Psychological Intervention for Paediatric Headache Cases: An Idiographic Ecological Momentary Study With Weekly Feedback Provision

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07418723
Acronym
HEAD-FLEX
Enrollment
5
Registered
2026-02-18
Start date
2024-02-09
Completion date
2025-04-30
Last updated
2026-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Primary Headaches (Includes Migraines, Tension, Cluster Headaches)

Keywords

headaches, pediatric, SCED, Disability, personalised, PBT, EMA, Longitudinal

Brief summary

This project was an empirical single-case experimental design (SCED) study conducted as part of a DClinPsy doctoral thesis completed by one of the researchers. The study used a brief and highly personalised psychological intervention for adolescents experiencing headaches. The aim was to understand how participants' real-time data could guide the personalised intervention provided to adolescents, including the development of skills to cope with headaches. The study began with an initial assessment of adolescents' (n = 6-8) headache experiences. Following this, the researchers formulated an individualised diagram for each participant to identify central problem areas or problematic responses relevant to their headaches. Based on these formulations, the team delivered a brief personalised intervention focused on developing adaptive psychological skills and coping responses. The intervention consisted of 4-5 weekly, 30-minute, one-to-one online sessions, targeting headache-related areas of concern. These sessions drew from established Cognitive Behavioural Therapy (CBT) and Acceptance and Commitment Therapy (ACT) interventions, both of which have previously been shown to reduce headache-related disability and improve functioning. During data collection, adolescents were prompted to complete brief online questionnaires on their smartphones. The questionnaires were personalised to each participant and measured specific psychological processes that had been identified as target areas during the assessment and formulation stages. This personalised data collection approach was then used to analyse individual-level changes and to explore how these changes facilitated progress in areas identified as important to each adolescent (e.g., school involvement or extracurricular activities). The study also examined whether overall headache-related disability decreased and whether daily functioning improved following the completion of the intervention.

Detailed description

Paediatric primary headaches represent a highly common health condition, affecting more than 62% of children and adolescents globally. These headaches contribute substantially to difficulties in day-to-day functioning, including disruptions in academic engagement and participation in social or leisure activities. Adolescents also report reductions in overall quality of life associated with recurrent headaches. Despite this significant burden, current psychological treatments demonstrate only small to medium effects in reducing headache-related impairment and improving quality of life. Progress in treatment efficacy has remained relatively limited. For example, although Cognitive Behavioural Therapy (CBT) is the recommended psychological approach for managing paediatric headaches, only around half of young people receiving CBT show meaningful improvements in disability and functional outcomes. This suggests that conventional delivery formats may not adequately address individual differences in needs and symptom patterns. Personalised psychological interventions-those tailored to the specific goals, characteristics, and difficulties of each individual-offer a promising avenue for optimising treatment effectiveness in young people. Such approaches focus on personally meaningful targets and select therapeutic components that best support progress toward those targets. A recent systematic review aggregating data across multiple studies provides evidence that personalised interventions can enhance outcomes linked to personally defined goals. However, research examining personalised treatment approaches specifically within paediatric populations remains limited. One emerging framework for delivering personalised care is Process-Based Therapy (PBT). PBT involves the ongoing identification and monitoring of the psychological, behavioural, and environmental processes that contribute to an adolescent's headaches-such as triggers, coping behaviours, contextual stressors, and emotional responses. This approach relies on regular, repeated data collection in adolescents' natural environments, which provides therapists with up-to-date information that can be used to guide treatment decisions. The 2012 NICE guidelines for headache management in individuals over 12 years old already recommend tracking headache severity, frequency, and duration with diaries, highlighting the value of continuous monitoring. Within our study, this ongoing assessment-feedback loop enabled therapists to observe short-term changes, refine hypotheses about maintaining processes, and adjust intervention components accordingly (e.g., introducing emotional regulation strategies if data indicated high emotional reactivity during headache episodes). PBT appears particularly suited to paediatric headache management, where adolescents often present with diverse symptom profiles and needs. Rather than constituting a new therapeutic model, PBT represents a shift in the delivery of therapy-emphasising the selection of targeted CBT-based strategies to influence key processes of change, rather than relying on standardised, protocol-driven, diagnosis-specific treatment packages. A defining feature of PBT is the use of continuous data collection methods such as Ecological Momentary Assessment (EMA). EMA involves gathering brief, real-time information multiple times per week in adolescents' everyday environments, enabling accurate capture of their moment-to-moment experiences. In addition to providing rich data for clinical decision-making, EMA has been shown to enhance young people's insight, self-awareness, and ability to self-manage headache-related difficulties. In this study, EMA was used to collect weekly data, supporting both progress monitoring and the ongoing tailoring of interventions to each adolescent's specific needs.

Interventions

BEHAVIORALPBT Personalised

Participants took part in up to five online brief therapy sessions, each focusing on the key processes identified during their initial assessment and refined throughout treatment. The intervention drew on evidence-based CBT-informed strategies for headache management, and clinical supervision was provided by the lead project supervisor. Because the approach was highly individualised, no fixed protocol was followed. Consistent with Process-Based Therapy, each adolescent's network map was treated as a dynamic formulation and was updated regularly. Weekly EMA data were collected between sessions and reviewed with participants to refine the map and guide session priorities. This integration of EMA feedback and evolving case formulation enabled a personalised and flexible intervention, informing the specific processes targeted and decisions about the overall direction of therapy.

Sponsors

Royal Holloway University
Lead SponsorOTHER
Great Ormond Street Hospital for Children NHS Foundation Trust
CollaboratorOTHER
The Hillingdon Hospitals NHS Foundation Trust
CollaboratorOTHER_GOV
UCLH
CollaboratorUNKNOWN

Study design

Allocation
NA
Intervention model
SEQUENTIAL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE

Intervention model description

This study employed a single-case experimental design (SCED) incorporating a combined multiple-baseline structure and Ecological Momentary Assessment (EMA) methodology. Each participant completed a baseline monitoring phase lasting between one and three weeks prior to receiving the intervention. During the study period, participants were asked not to begin any other psychological treatment for headaches to avoid confounding effects.

Eligibility

Sex/Gender
ALL
Age
12 Years to 18 Years
Healthy volunteers
No

Inclusion criteria

* Adolescents aged 12-18. * Recurrent headaches occurring for 3 months or more, ideally (but not necessarily) diagnosed as a primary headache by a Neurologist. * The headache should be deemed to be resulting from a primary headache disorder as opposed to a secondary symptom of another health condition. No current or prior engagement with psychological support for headache for up to 6 months before screening. * Experiencing at least minimal disability or interference from headaches (e.g. PedMIDAS score of greater than 10 points * Adolescents and their caregiver fluent in speaking and writing in English. * Frequent access to a smartphone with consistent internet access.

Exclusion criteria

* Aged younger than 12 or older than 18. * Presence, history or suspicion of secondary headache disorder. * Receiving psychological support for headaches or having prior engagement with psychological support for headaches up to 6 months before screening. * An indication of a need for multisystemic therapies (e.g. a PedMIDAS score of 140) * Diagnosis of pervasive developmental disorder or serious mental health difficulty (e.g., psychosis, active suicidal thoughts) as determined by the referrer. * Adolescents living in families experiencing significant distress or psychosocial issues. * Adolescents and their carer not fluent in speaking and writing in English. * Limited access to a smartphone device with a consistent internet connection.

Design outcomes

Primary

MeasureTime frameDescription
Perceived progress in a personally defined goal (Visual analogue scale, one item 0-100).From enrollment to the end of the 1 month follow-upThis is one visual analogue scale as per ecological momentary assessment suggestions. A higher score in this item denotes higher perceived progress in personally defined goals.
Perceived ability to cope with headache (one visual analogue item - 0-100)From enrolment till the end of 1 month follow-upThis is one visual analogue item as per the ecological momentary assessment suggestions. A higher score in this item denotes higher perceived ability to cope with headaches.
Perceived headache interference (one visual analogue item - 0-100)From enrolment till the end of 1 month follow-upThis is one visual analogue scale as per ecological momentary assessment suggestions. A higher score in this item indicates lower interference of headache in daily life activities.
Headache activity (2 items visual analogue scale- 0-100: headache frequency and intensity)From enrolment till the end of 1 month follow-upWe measured headache frequency and headache intensity every 3 days. For headache frequency, participants were asked to state the number of episodes they have had in a week (e.g."1 episode"). Headache intensity was measured on a visual analogue scale (VAS )from 0 to 100, where 0 represented "no headache" and 100 represented "extreme pain". This is a reliable and valid method to obtain a self-report measure of pain in paediatric samples (von Baeyer, 2009). A higher score in these two items indicates higher headache frequency and intensity, respectively.

Secondary

MeasureTime frameDescription
Paediatric Pain Interference (PPI)From enrollment once per week till the end of 1 month follow-upThe Patient Reported Outcomes Measurement Information System (PROMIS) Paediatric Pain Interference (PPI) 8 Item Bank measures the daily interference of pain on physical, psychological, and social functioning. Each item is scored on a 1-5 Likert scale ranging from "never" to "almost always", with min and max scores ranging from 8 to 40. Higher scores indicate greater pain interference. This is a unidimensional item bank which has been validated in paediatric chronic pain samples and has been shown to have good internal consistency (Cronbach's alpha= 0.9).
Paediatric Migraine Disability Assessment Scale (PedMIDAS)From enrollment once per week till the end of 1 month follow-upThe Paediatric Migraine Disability Assessment Scale (PedMIDAS) is a 6-item questionnaire measuring the frequency of disruption (using days as the unit) to daily activities caused by headache. The scores range from 0-240, where \>50 indicates severe impairment, 31-50 moderate, 11-30 is mild, and 0-10 is little to no impairment. The PedMIDAS has been shown to have internal consistency (Cronbach's alpha 0.80) and validity in measuring headache-related disability. While the PedMIDAS asks individuals to retrospectively estimate disruption to daily activities over a period of 3 months, we adapted the questionnaire to ask individuals to estimate disruption over a one-week period, to increase sensitivity to changes within shorter time periods.

Countries

United Kingdom

Contacts

STUDY_CHAIRJess Kingston, Ph.D.

Royal Holloway University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Aug 19, 2026