Sedentary Individuals Not Participating in Regular Exercise Training/Physical Activity
Conditions
Keywords
cardiorespiratory fitness, cardiometabolic health, exercise training, exercise intensity
Brief summary
The aim of this randomized controlled intervention study is to examine the minimum exercise intensity that has an effect on cardiorespiratory fitness and/or cardiometabolic risk factors in sedentary adults. In addition, the study seeks to examine which background factors explain individual differences in exercise responses.
Detailed description
The study consists of a 2-week baseline period followed by two 6-week intervention periods. The study will compare changes in the predefined outcome variables between the exercise intervention groups and the control group that does not perform any exercise training. In addition to intensity prescribed relative to oxygen uptake reserve, exercise intensity will be retrospectively analyzed in relation to the first ventilatory threshold in order to examine the lowest effective intensity using this method as well. Among background factors, possible modifiers assumed on the basis of previous literature, will be analyzed to assess their contribution to inter-individual differences in the outcome responses. Potential main contributors are considered to be sex, the basal value of the outcome, nutritional habits, physical activity and stationary behavior outside the prescribed training, and non-invasive indicators of stress.
Interventions
OTHERExercise
6 weeks of 3 x 30 min/week supervised cycle ergometer training and 6 weeks of 3 x 40-50 min/week supervised cycle ergometer training
Sponsors
UKK Institute
Paavo Nurmi Center & Unit for Health and Physical Activity
Juho Vainion säätiö
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
SINGLE (Subject)
Intervention model description
Four parallel intervention groups and control group
Eligibility
Sex/Gender
ALL
Age
30 Years to 55 Years
Healthy volunteers
Yes
Inclusion criteria
* 30-50-year old males and females * Sedentary, not participating in regular exercise training/physical activity
Exclusion criteria
* Cardiovascular symptoms/diseases * Musculoskeletal symptoms/diseases * Metabolic diseases * Resting blood pressure \> 160/100 mmHg * Body mass index ≥ 35
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Ventilatory thresholds | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Assessed with step-ramp-step protocol |
| Maximal oxygen consumption | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Assessed with step-ramp-step protocol |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Concentration of total cholesterol | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Fasting state blood sample |
| Concentration of triglycerides | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Fasting state blood sample |
| Pmax | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Maximum power of the ramp cycle ergometer test |
| Concentration of blood glucose | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Fasting state blood sample |
| Concentration of insulin | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Fasting state blood sample |
| HOMA-IR | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | (Insulin × Glucose) / 22.5 |
| HbA1c | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Fasting state blood sample |
| Blood pressure | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Systolic and diastolic blood pressure |
| Resting heart rate | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | In sitting position |
| Resting heart rate variability | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Root mean square of successive differences in sitting position |
| Gross efficiency | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Gross efficiency during standard load |
| Body weight | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Measured using an electronic scale. |
| Concentration of LDL cholesterol | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Fasting state blood sample |
| Waist circumference | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | — |
| Concentration of HDL cholesterol | Pre (week 0), mid (after 6 weeks), post (after 12 weeks) | Fasting state blood sample |
Countries
Finland
Contacts
CONTACTOlli-Pekka S Nuuttila, PhD
Outcome results
None listed