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PPV vs PVI in the Supine and Prone Position

Variability and Correlation of the Pulse Pressure Variability (PPV) and the Plethysmography Variability Index (PVI) in the Supine and Prone Position

Status
Enrolling by invitation
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07415603
Enrollment
100
Registered
2026-02-17
Start date
2026-07-09
Completion date
2029-05-31
Last updated
2026-09-09

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Surgeries Undergoing General Anesthesia

Brief summary

This is a prospective study that will record the Pulse Pressure Variability (PPV) from the arterial line and Plethysmography Variability Index (PVI) from the pulse oximeter while the patient is in the supine position and then again in the prone position. There will be no change in anesthetic care based on the study protocol. The primary objective of this study is to evaluate the changes in PVI and PPV when changing from the supine and prone position in pediatric-aged patients.

Interventions

OTHERObservation

No intervention

Sponsors

Joseph D. Tobias
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Healthy volunteers
No

Inclusion criteria

* Consenting ASA 1-4 patients * Undergoing a surgical procedure with general anesthesia that requires placement of an arterial cannula and prone positioning

Exclusion criteria

* Patients in whom an arterial cannula is not indicated or cannot be placed * Patients undergoing a surgical procedure that does not require prone positioning

Design outcomes

Primary

MeasureTime frameDescription
PPV SupineOnce a minute for 5 minutesPulse Pressure Variability (PPV) recorded from the arterial line while supine.
PVI SupineOnce a minute for 5 minutesPlethysmography Variability Index (PVI) recorded from the pulse oximeter while supine.
PPV ProneOnce a minute for 5 minutesPulse Pressure Variability (PPV) recorded from the arterial line while prone.
PVI ProneOnce a minute for 5 minutesPlethysmography Variability Index (PVI) recorded from the pulse oximeter while prone.

Countries

United States

Contacts

PRINCIPAL_INVESTIGATORJoseph Tobias, MD

Nationwide Children's Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 10, 2026