Soft Tissue Healing
Conditions
Keywords
fixed partial denture, pontic site, low-level laser therapy, clinical trial
Brief summary
This randomized placebo-controlled clinical trial aimed to evaluate the effect of laser-assisted therapy on soft tissue healing at the pontic site prior to fixed partial denture rehabilitation. Clinical healing outcomes, postoperative pain levels, and gingival crevicular fluid transforming growth factor beta-2 (TGF-β2) levels were assessed to determine the biological and clinical effects of laser therapy compared with placebo.
Detailed description
Delayed or compromised soft tissue healing at the pontic site may prolong prosthetic treatment and negatively affect tissue stability and patient comfort. Photobiomodulation has been reported to enhance wound healing and modulate inflammatory and regenerative processes. This randomized placebo-controlled clinical trial evaluated the clinical and biological effects of laser-assisted therapy on pontic site healing prior to fixed partial denture rehabilitation. Clinical healing index scores, wound dimensions, postoperative pain levels, and gingival crevicular fluid TGF-β2 levels were assessed to investigate both clinical and biological aspects of healing.
Interventions
DEVICEGRR laser
Low-level laser therapy applied once daily for five consecutive days following tooth extraction to enhance soft tissue healing at the pontic site.
DEVICENd:YAG laser
Nd:YAG laser therapy applied once daily for five consecutive days following tooth extraction to promote soft tissue healing.
OTHERSham laser
Placebo laser application performed under identical conditions without energy delivery.
Sponsors
University of Gaziantep
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Subject)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Adults aged 18 years or older * Patients requiring single-tooth extraction followed by fixed partial denture rehabilitation * Patients in good general health * Patients willing to participate and able to provide informed consent
Exclusion criteria
* Presence of systemic diseases that may affect wound healing (e.g., uncontrolled diabetes, immunological disorders) * Active periodontal disease at the study site * Use of medications affecting wound healing * Smoking or tobacco use * Pregnancy or lactation * History of radiotherapy in the head and neck region * Known contraindications to laser therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Clinical healing index (Landry, Turnbull and Howley Healing Index) | Baseline, Day 7, Day 14 | Clinical healing was assessed using the Landry, Turnbull and Howley Healing Index, which provides a single composite ordinal score ranging from 1 to 5, where higher scores indicate better soft tissue healing. The score is determined based on clinical evaluation of tissue color, bleeding on palpation, presence of granulation tissue, and degree of epithelialization at the pontic site. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Wound size reduction | Baseline, Day 7, Day 14 | Measurement of wound dimensions at the pontic site to evaluate soft tissue healing. |
| Postoperative pain (VAS) | Baseline, Day 7, Day 14 | Postoperative pain intensity was assessed using a Visual Analog Scale (VAS) ranging from 0 to 10, where 0 indicates no pain and 10 indicates the worst imaginable pain. Higher scores indicate greater pain intensity. |
| Gingival crevicular fluid TGF-β2 levels | Baseline, Day 7, Day 14 | Biochemical evaluation of transforming growth factor beta-2 levels in gingival crevicular fluid to assess biological aspects of wound healing. |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORİREM KARAGÖZOĞLU
University of Gaziantep
Outcome results
None listed