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Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages

Improving LDL-C Levels Through Temporal Self-regulation Theory-based, Personality-tailored Health Messages: A Three-Arm Randomized Controlled Trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07415109
Enrollment
3000
Registered
2026-02-17
Start date
2025-11-25
Completion date
2028-11-01
Last updated
2026-04-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Adherence, Preventive Health Services

Brief summary

The study is meant to run parallel to the larger study, RESET. The goal of this study is to to evaluate the effectiveness of a once-off general and personality-tailored text message on GP consultation among RESET participants identified to have high LDL-C. The main question it aims to answer is: Will participants exposed to personality tailored advice have a higher adherence to GP consultation compared to the participants in the control group? Researchers will compare a personalized message to a general message (with no personalization according to patients personality type) and control group to see if the messages increase adherence. Participants are required to complete two questionnaires: one before and one after they receive their RESET results.

Interventions

BEHAVIORALGeneral Message

The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The general health message will include indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. The infographic will be included in the same ROR email.

BEHAVIORALPersonalized Message

The intervention will consist of messages and infographics embedded in participants' return of results (ROR) emails within the RESET study. Each participant will receive the ROR alongside the intervention once, at the time their results are sent. No repeat messages will be delivered. The message will include the personality-tailored message with the same core content as the general message, including indications for lipid therapy, benefits of lipid-lowering medications, common side effects, risks of non-adherence, and an infographic on diet and lifestyle modification based on ACE lipid management guidance. An infographic will be included in the same ROR email. This message will contain an added component framed according to conscientiousness and neuroticism scores, as these traits are strong predictors of health behaviours. Scores will be derived from baseline BFI-44 results.

Sponsors

National University Health System, Singapore
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
21 Years to 65 Years
Healthy volunteers
No

Inclusion criteria

* New participants of RESET who have given consent to be contacted for future studies * ≥21 years old

Exclusion criteria

* are not able to read, write or communicate in English

Design outcomes

Primary

MeasureTime frameDescription
Intention to adopt a healthier dietFrom enrollment to 3 months after results have been returned.A 3-item, 7-point Likert scale assessing participants' intention to adopt a healthier diet. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to adopt a healthier diet.
Intention to engage in Physical ActivityFrom enrollment to 3 months after results have been returned.A 3-item, 7-point Likert scale assessing participants' intention to engage in physical activity. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to engage in physical activity.
Intention to visit a General Practitioner3 months after results have been returned.A 3-item, 7-point Likert scale assessing participants' intention to visit a general practitioner. The minimum and maximum score one can attain on this measure is 3 and 21 respectively, with a higher score indicating higher intention to visit a general practitioner.

Countries

Singapore

Contacts

CONTACTJocelyn Chew
dbi-lab@nus.edu.sg+6565168687

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Apr 14, 2026