Aging, Cognitive Change, Sleep Disturbance
Conditions
Keywords
dementia, depression, brain structure, system biology
Brief summary
This project aims to build up the comprehensive health database of geriatric medicine for middle-aged and elderly people in Taiwan.
Detailed description
This project aims to establish a comprehensive local health database for adults aged 40 and above by integrating clinical data, functional assessments, genomics, metabolomics, and gut microbiome profiles. The project focuses on validating metabolomic and genetic biomarkers associated with sarcopenia and developing predictive models for early risk identification. Longitudinal multi-omics analyses will be conducted using blood, urine, and fecal samples to explore metabolic dynamics and their links to aging-related conditions. In parallel, the study examines brain health and psychosocial factors, including sleep, resilience, apathy, and loneliness, to better understand their roles in cognitive function and healthy aging. Through the integration of large-scale health data and advanced analytical approaches, this project aims to support early detection, personalized intervention strategies, and the development of precision healthy aging models.
Interventions
None listed
Sponsors
Chang Gung Memorial Hospital
Chang Gung University
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Willing to sign a written participant consent form. * Males or females aged 40 or above who have participated in the "Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging (Pilot Project)," the "Integrated Systematic Geriatric Medical Information to Explore Solutions for Healthy Aging" master planner, or the "Integrated Systematic Medical Information to Explore Solutions for Healthy Aging" project (not subject to
Exclusion criteria
). * Males or females aged 40-59 who have participated in health checkups for employees of Chang Gung Memorial Hospital, Formosa Plastics Group, or Chang Gung University. * Those with a medical record of more than one year at Chang Gung Memorial Hospital. * Those who have resided in Taiwan for more than 180 days in the past year.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The brain volume of local Taiwanese aged over 40 years old | one hour | Measure the volume of cerebrum, cerebellum, and skin of skull (unit in mm3) by magnetic resonance imaging |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The actigraphy of local Taiwanese aged over 40 years old | two weeks | Measure the circadian rhythm (unit in minute) by Actiwatch |
| The sleep quality questionnaire of local Taiwanese aged over 40 years old | one day | Measure the sleep quality (unit in score) by Pittsburgh Sleep Quality Index (PSQI, Score range: 0 \~ 21, higher is worse) |
| The gut microbiota of local Taiwanese aged over 40 years old | one day | Fecal samples were analyzed using 16s full length rRNA gene sequencing to characterize the composition and diversity of the gut microbiota |
| The metabolism of local Taiwanese aged over 40 years old | one day | Nuclear Magnetic Resonance (NMR) spectroscopy was employed to perform metabolic profiling of blood samples, with metabolite concentrations quantified in mg/dL, respectively |
| The mental/neurocognitive condition questionnaire of local Taiwanese aged over 40 years old | one day | Measure the mental/neurocognitive condition (unit in score) by Mini-Mental State Examination Score (MMSE, Score range: 0 \~ 30, higher is better) |
Countries
Taiwan
Contacts
CONTACTJI-TSENG FANG, Professor
Outcome results
None listed