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Association Between Slow Wave Activity and Sleep Inertia

Association Between Slow Wave Activity and Sleep Inertia in Nighttime Simulated Naps: An Observational Study With Nap Intervention

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07409883
Enrollment
28
Registered
2026-02-13
Start date
2026-02-04
Completion date
2026-08-30
Last updated
2026-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Night Shift Work, Sleep Inertia, Sleep, Slow-wave Sleep, Sleep Enhancement, Sleep Optimization

Keywords

sleep inertia, nap

Brief summary

Observational study: The goal of this observational study is to learn about the association between slow wave activity before awakening and post-awakening psychomotor vigilance task in time-fixed, 2-hour, simulated night naps in healthy individuals. The main question aims to answer is: Is the quantity of slow wave activity immediately before awakening associated with post-awakening psychomotor vigilance task metrics when awakened after 2-hour nap at night?

Detailed description

Sleepiness and fatigue are common complaints among shift workers, especially night shift workers. Napping interventions before a work shift have been reported to increase alertness and reduce accidents. However, naps may also result in impaired cognition for a brief period immediately after awakening, known as "sleep inertia", which can be particularly problematic in on-call settings and may require a worker to delay the return to work for up to about 30 minutes after waking. Although, nap duration less than 30 minutes, theoretically, may produce less intense sleep inertia. However, evidence regarding nap duration aiming to mitigate sleepiness and fatigue is mixing. We thus aimed to investigate the association between slow wave activity (SWA) assessed by EEG power spectral analysis during the last 10 minutes before awakening and 10-minute psychomotor vigilance test (PVT) immediately after awakening and 30 minutes after awakening in healthy participants on simulated night shift scenarios.

Interventions

BEHAVIORALNap intervention

Nap intervention is the protocol that allows the participant to sleep from 11:00 PM to 2:00 AM, then woken up.

Sponsors

Mahidol University
Lead SponsorOTHER
Ramathibodi Hospital
CollaboratorOTHER

Study design

Observational model
CASE_ONLY
Time perspective
CROSS_SECTIONAL

Eligibility

Sex/Gender
ALL
Age
18 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

1. Age between 18 and 60 years 2. History of appropriate sleep duration at least 6 hours/night for a minimum of 2 weeks assessed by sleep diary before the trial

Exclusion criteria

1. STOP-BANG ≥3 or previous diagnosis of obstructive sleep apnea 2. Presence of restless legs syndrome as assessed with IRLSSG criteria 3. Presence of depression as assessed by HADS (Exclude participants with HADS-Depression sub-scale score ≥8 (possible depression) 4. History of irregular work hours or shift work within 2 weeks 5. Use of sedative/hypnotic medications on a regular-basis (3 days/week or above) 6. History of epilepsy and brain tumor

Design outcomes

Primary

MeasureTime frameDescription
psychomotor vigilance test (PVT)Psychomotor vigilance test (PVT) will be assessed 2 times: 1) immediately after awakening, and 2) at 30 minutes after awakening.To investigate the association between slow wave activity (SWA) as assessed by electroencephalographic power spectral analysis during the last 10 minutes before awakening and a 10-minute psychomotor vigilance test (10-min PVT) immediately after awakening and 30 minutes after awakening in healthy participants on simulated night shifts

Countries

Thailand

Contacts

CONTACTPongsakorn Tanayapong, Doctor of Medicine
pongsakorn.taa@mahidol.ac.th(66)-64-9626525

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026