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Pain Relief Following Laparoscopic Cholecystectomy While Comparing Intra Abdominal Versus Sub Cutaneous Local Anesthetic Administration

Comparative Evaluation of Analgesic Outcomes of Intra-peritoneal Versus Subcutaneous Infiltration of Bupivacaine for Laparoscopic Cholecystectomy Patients "

Status
Recruiting
Phases
Phase 4
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07409688
Enrollment
100
Registered
2026-02-13
Start date
2026-01-17
Completion date
2026-06-17
Last updated
2026-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Analgeisa, Laparoscopic Cholecystectomy Surgery, Local Anesthetic Infiltration

Keywords

Laparoscopic cholecystectomy, Post Operative analgesia, Local anesthetic administration

Brief summary

Laparoscopic cholecystectomy involves removal of gallbladder through small incision ports resulting in faster recovery. Small incisions are less painful and hence local anesthesis administered can be effective for pain management. This local anesthetic can be administered either within abdominal cavity or at sit of small incisions.

Detailed description

Laparoscopic cholecystectomy is a minimally invasive surgical procedure involving removal of the gallbladder through multiple small trocar incisions. Compared with open surgery, this approach is associated with reduced postoperative pain, shorter hospital stay, and faster recovery. Despite its minimally invasive nature, postoperative pain remains a significant concern, particularly at port sites and from intraperitoneal irritation. Local anesthetic techniques have been shown to contribute to multimodal analgesia in laparoscopic surgery. Local anesthetic agents may be administered either intraperitoneally or by infiltration at trocar insertion sites to reduce postoperative pain and opioid requirements. However, the optimal route of local anesthetic administration for effective postoperative analgesia following laparoscopic cholecystectomy remains uncertain, warranting further clinical evaluation.

Interventions

DRUGIntraoperitoneal local anesthetic administration

Intraperitoneal infiltration of 20ml of 0.25% Bupivacaine will be done at the end of procedure by the surgeon.

DRUGSub cutaneous administration of local anesthetic

port site infiltration of 20ml of 0.25% Bupivacaine will be done. 6ml for 10mm ports and 4ml for 5mm ports respectively.

Sponsors

Rawalpindi Medical College
Lead SponsorOTHER

Study design

Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)

Eligibility

Sex/Gender
ALL
Age
15 Years to 60 Years
Healthy volunteers
Yes

Inclusion criteria

* ASA I and II

Exclusion criteria

* Allergic to local anesthetic Open cholecystectomy History of chronic pain History of abdominal surgery

Design outcomes

Primary

MeasureTime frame
Post opestive pain scoreThis will be measured using Visual Analog score upon arrival at post anesthesia care unit labelled as Time 0 then at time intervals 3h,6h, 12h and 24 hours post operatively
Rescue analgesia demandThis will be the number of patients requiring resuce analgesia in 24h post operative period. Rescue analgesia will be administered if VAS score >4

Countries

Pakistan

Contacts

CONTACTNimrah Iqbal Prinicpal Investigator, MBBS
drnimrahiqbal@gmail.com+92 335 0526611
STUDY_CHAIRWaqas Anjum

Rawalpindi Medical College

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026