HIV Prevention, Substance Use
Conditions
Brief summary
This study includes finalization of the LINKED social network intervention to improve PrEP and MOUD uptake among people who inject drugs (PWID) in collaboration with an Expert Advisory Board and staff (N=16) at The Sidewalk Project (TSP), followed by a Hybrid Type II cluster randomized trial of the LINKED intervention (versus an equal-attention control) among N=372 people who inject drugs, with 6- and 12-month follow-up assessment of PrEP and MOUD uptake. The investigators will also evaluate implementation outcomes to inform future sustainable implementation of LINKED in harm reduction organizations.
Interventions
BEHAVIORALLINKED
LINKED is a theory-driven social network intervention (SNI) that leverages peer influence within the social networks of people who inject drugs (PWID) to disseminate information, encourage communication, and increase pre-exposure prophylaxis (PrEP) and medications for opioid use disorder (MOUD) uptake and persistence in harm reduction organization (HRO) settings.
BEHAVIORALGroup Intervention
Group intervention facilitated by trained study staff that supports critical thinking about what constitutes low, medium, and high risks for HIV and overdose.
Sponsors
NYU Langone Health
National Institute on Drug Abuse (NIDA)
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Aim 1 - Virtual Focus Group * Is 18 years or older * Is a current TSP staff * Is capable and willing to provide consent Aim 2 - Intervention * 18 years or older * Spend majority of their time in the Los Angeles, CA area where recruited * Able to complete surveys and group sessions in English * Self-report to have injected drugs in the past 3 months * Self-reported HIV negative serostatus * Not currently on PrEP or MOUD * Not pregnant * If a network recruit: presents a valid recruitment coupon * Is capable and willing to provide consent Aim 3 - Virtual Focus Group/Surveys * Is 18 years or older * Is a current TSP staff * Is capable and willing to provide consent
Exclusion criteria
Aims 1 and 3: • Individuals who are not current TSP staff members will be excluded from participation. Aim 2: * Under age 18; * Does not spend majority of time in the Los Angeles, CA area where recruited; * Unable to complete surveys and groups sessions in English; * Does not self-report injecting drugs in past 3 months; * Self-reported HIV positive serostatus * Currently on PrEP or MOUD * Currently pregnant * If a network recruit: does not present a valid recruitment coupon
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Percentage of Participants with PrEP Uptake | Month 6 | Measured via filled PrEP prescription. |
| Percentage of Participants with MOUD Uptake | Month 6 | Measured via filled MOUD prescription or buprenorphine, methadone, or naltrexone enrollment. |
| Percentage of Participants with PrEP Adherence | Month 6 | Measured via urine immunoassays to test for oral PrEP. |
| Percentage of Participants with MOUD Adherence | Month 6 | Measured via urinalysis to test for metabolites for MOUD. |
Countries
United States
Contacts
CONTACTSuzan Walters, PhD
PRINCIPAL_INVESTIGATORSuzan Walters, PhD
NYU Langone Health
Outcome results
None listed