Parkinson Disease
Conditions
Keywords
Deep Brain Stimulation
Brief summary
The goal of this study is to learn more about the brain activity underlying Parkinson's disease risk taking and reward seeking behaviors. The investigators will utilize neural recordings from corticostriatal structures performed during deep brain stimulation surgery to measure neural activity underlying nonmotor symptoms of Parkinson's disease.
Interventions
Neurophysiology recordings will be performed during deep brain stimulation surgery and their relationship to performance on a gambling task evaluated
OTHERNeural stimulation
Neural stimulation will be delivered during a gambling task and its impact on task performance quantified
Sponsors
Vanderbilt University Medical Center
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
40 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Scheduled to undergo deep brain stimulation surgery under local anesthesia at Vanderbilt University Medical Center * Planned clinical electrode trajectory that contacts caudate * Age greater than or equal to 40 * Diagnosis of Parkinson's disease or other movement disorder * Able to participate in intraoperative testing * English speaking
Exclusion criteria
* Age less than 40 * Not able to participate in intraoperative testing (for example unable to comprehend instructions or follow directions)
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Changes in caudate DLPFC beta coherence | Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours | Caudate DLPFC coherence will be computed at rest and during the gambling task and correlated with cognitive metrics |
| Changes in gambling task performance with neural stimulation | Baseline to end of Deep Brain Stimulation (DBS), approximately 3-4 hours | The gambling task will involve seeing a series of cards presented on the screen and pressing a button to respond with a bet. Gambling task performance will be compared between stimulated and non stimulated blocks and between stimulation targets |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in beta power with neural stimulation | Baseline to end of deep brain stimulation (DBS) surgery, approximately 3-4 hours | Beta power will be computed and compared between stimulation on and off conditions for different targets |
Countries
United States
Contacts
CONTACTLucas Chang, BA
CONTACTSarah Bick, MD
PRINCIPAL_INVESTIGATORSarah Bick
Vanderbilt University Medical Center
Outcome results
None listed