Effect of Injectable Platelet Rich Derivatives on Orthodontic Canine Retraction

The Effect of Injectable Platelet Rich Derivatives on the Rate of Orthodontic Canine Retraction: A Split-Mouth Randomized Controlled Trial

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07408895

Enrollment

Registered

2026-02-13

Start date

2024-05-30

Completion date

2024-09-05

Last updated

2026-02-13

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Accelerate Tooth Movement

Brief summary

This study evaluated the effect of injectable platelet-rich derivatives on the rate of orthodontic canine retraction. Patients requiring orthodontic canine retraction following premolar extraction were enrolled and divided into three groups using a split-mouth design. Injectable platelet-rich plasma (PRP) and platelet-rich fibrin (PRF) were applied to compare their effects on the rate of tooth movement. The outcomes were assessed by measuring the amount of canine retraction over time.

Interventions

BIOLOGICALPlatelet-Rich Plasma (PRP)

Autologous platelet-rich plasma prepared from the patient's own blood and injected locally at the experimental side to accelerate orthodontic canine retraction.

BIOLOGICALPlatelet-Rich Fibrin (PRF)

Autologous platelet-rich fibrin prepared from the patient's own blood and injected locally to accelerate orthodontic canine retraction.

Study design

Allocation

RANDOMIZED

Intervention model

CROSSOVER

Primary purpose

TREATMENT

Masking

NONE

Intervention model description

Split-mouth randomized controlled design in which different interventions were applied to opposite sides within the same participant.

Eligibility

Sex/Gender

ALL

Age

17 Years to 29 Years

Healthy volunteers

Inclusion criteria

* Healthy individuals aged 17-29 years (mean age 24 ± 6 years) * Diagnosis of Class I bimaxillary protrusion or Class II division 1 requiring first premolar extractions * Full permanent dentition * Good oral hygiene * Non-smokers * Not taking medications affecting bone metabolism (e.g., bisphosphonates)

Exclusion criteria

* Pregnancy or breastfeeding * Contraindications to platelet therapies (e.g., platelet dysfunction) * Severe malocclusion unsuitable for fixed appliances * Dental anomalies (size/shape) * Systemic syndromes

Design outcomes

Primary

Measure	Time frame	Description
Rate of Orthodontic Canine Retraction	From baseline (initiation of orthodontic canine retraction) until completion of canine retraction, assessed monthly for up to 4 months.	The amount of orthodontic canine movement measured in millimeters.

Countries

Yemen

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 14, 2026