Homemade Herbal Mouthwash in Gingivitis. A Randomized Clinical Trial.

The Effect of Homemade Herbal Mouthwash Versus Chlorhexidine on Plaque Accumulation in Gingivitis. A Randomized Clinical Trial.

Status

Not yet recruiting

Phases

Phase 3

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07401069

Enrollment

Registered

2026-02-10

Start date

2026-02-01

Completion date

2026-07-30

Last updated

2026-02-10

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Gingivitis

Brief summary

Gingivitis is a very common oral disease that may progress to the more destructive periodontitis if not treated. As oral plaque is a key player in gingivitis, plaque control by professional scaling and oral hygiene measures represents the main line of treatment. Among the oral hygiene measures, using chlorhexidine mouthwash is considered the gold standard in mouthwashes. However, due to its side effects, a safer and more acceptable mouthwash is needed. Therefore, this study proposes mouthwashes made of infusion of natural herbs as an alternative.

Interventions

DRUGChlorhexidine 0,12%

chlorhexidine 0.12% mouthwash twice daily for 7 days

DRUGherbal Mouthwash

Mouthwash made at home by boiling herbs in water and then saving the solution in a tightly closed container for daily use for 7 days

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Outcomes Assessor)

Eligibility

Sex/Gender

ALL

Age

20 Years to No maximum

Healthy volunteers

Inclusion criteria

* Plaque-induced gingivitis.

Exclusion criteria

* Medically compromised. * History of medications. * Pregnant females. * Periapical involvement in teeth. * History of periodontal surgery. * If gingivitis was due to local factor.

Design outcomes

Primary

Measure	Time frame	Description
plaque index (O'Leary et al., 1972)	7 days	Plaque accumulation is tested on teeth with a probe. Number of sites having plaque accumulation will be divided by the total number of dental sites to get percentage of plaque accumulation.

Secondary

Measure	Time frame	Description
Bleeding on probing	7 days	Bleeding on probing is tested on teeth with a periodontal probe. Number of sites showing bleeding will be divided by the total number of dental sites to get percentage of bleeding on probing.
Changes in clinical signs of inflammation (Armitage, 2004)	7 days	Results will be in the form of (Yes/No); indicating if the gingival clinical condition (color and contour) was improved or not
Bleeding on brushing	7 days	Evaluation of extent of daily bleeding on brushing using VAS.
Patient's acceptance of the mouthwash	7 days	questionnaire

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 11, 2026