Lung Cancer (NSCLC), Radiation
Conditions
Brief summary
The purpose of this study is to assess a real time motion tracking of lung tumors and important organs next to the tumor while breathing during a participant's radiation treatment. This will be assessed through a four-dimensional magnetic resonance imaging (MRI) scan before starting your radiation treatment and x-ray fluoroscopy images that are taken during radiation
Interventions
OTHERMRI
Baseline 4D CT Simulation and 4S MRI with surface monitoring through EndoScout vest, followed by fluoroscopy and additional surface monitoring while undergoing daily radiation.
Sponsors
University of Maryland, Baltimore
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
1. Adult (≥18 years) patients (both sexes) with histologically diagnosed Stage II-IIIb NSCLC 2. Patients to be treated with definitive external beam photon radiotherapy with or without systemic therapy (e.g., chemotherapy, immunotherapy). 3. No restrictions on number radiotherapy fractions, or location/number of lesions 4. ECOG performance status ≤ 3 5. Ability to undergo MRI scans 6. Patient has signed informed consent document and agreed to study procedures
Exclusion criteria
1. Pre-existing contraindications for MRI, such as any MRI-conditional or MRI-unsafe foreign objects within the body, non-removable ear cochlear or eye implant, aneurysm clip, cardiac pacemaker/wires, internal defibrillator, tissue expander, recent stent placement, penile prosthesis, medication patch, artificial limb, pregnancy, and claustrophobia 2. Women who are pregnant or trying to get pregnant (self-reported) 3. Pain in supine position or inability to raise arm above head in supine position
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To investigate if time-resolved, multicycle volumetric motion modeling and monitoring gives improved spatiotemporal localization of the tumor target and OARs compared to current standard-of-care 4DCT-based motion modeling and monitoring | 3 years |
Countries
United States
Contacts
CONTACTAmit Sawant, PhD
CONTACTCaitlin Eggleston, MPH
PRINCIPAL_INVESTIGATORAmit Sawant, PhD
University of Maryland, Baltimore
Outcome results
None listed