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Study of the Association Between Sacroiliitis/Axial Spondylarthritis and Giant Cell Arteritis/ Polymyalgia Rheumatica

Study of the Association Between Sacroiliitis/Axial Spondylarthritis and Giant Cell Arteritis/ Polymyalgia Rheumatica: A Case-control Observational Study

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07394478
Acronym
SAGE PPR
Enrollment
10
Registered
2026-02-06
Start date
2026-02-01
Completion date
2026-06-30
Last updated
2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Giant Cell Arteritis (GCA), Polymyalgia Rheumatica, Spondylarthritis

Keywords

Giant Cell Arteritis (GCA), Spondylarthritis, Polymyalgia rheumatica

Brief summary

The purpose of the study is to recruit as many patients as possible presenting with sacroiliitis or authentic axial spondylarthritis and giant cell arteritis. The investigators will also be interested in the association of spondylarthritis and polymyalgia rheumatica given the continuum between these two pathologies. The aim is to investigate whether there is an association between giant cell arteritis and spondylarthritis or polymyalgia rheumatica and spondylarthritis.

Detailed description

Large vessel vasculitis primarily includes Takayasu's arteritis and Giant Cell Arteritis (GCA). The literature describes associations between spondyloarthritis and large vessel vasculitis, particularly with Takayasu's arteritis. Case reports have highlighted specific features in patients presenting with both conditions, such as an older age at spondyloarthritis diagnosis and higher C-reactive protein (CRP) levels, for example. However, to date, no cases of axial spondyloarthritis associated with confirmed GCA have been reported in the literature. The investigators plan to recruit cases (patients with GCA and/or polymyalgia rheumatica \[PMR\] plus spondyloarthritis) and controls (patients with GCA or PMR alone). The investigators will then analyze their characteristics to investigate a potential association between these diseases.

Interventions

OTHERDescription of population

Description of population in the aim of identify demographic or phenotypic factors different between experimental and control populations.

Sponsors

Hôpital NOVO
Lead SponsorOTHER
GEFA
CollaboratorUNKNOWN
CRI
CollaboratorUNKNOWN

Study design

Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* Experimental group: Adult patient with spondylitis associated with GCA or PMR Control group: Adult patient with GCA or PMR

Exclusion criteria

* Refusal to participate * Positive anti CCP

Design outcomes

Primary

MeasureTime frameDescription
Description of the population of patients with spondylarthritis associated with giant cell arteritis (GCA) or polymyalgia rheumatica (PMR) versus patients with GCA or PMR aloneAt baselineIdentification of demographic or phenotypic factors different between experimental and control populations.

Countries

France

Contacts

CONTACTMathilde WLODARCZYK
mathilde.wlodarczyk@ght-novo.fr0033130754650
PRINCIPAL_INVESTIGATOROmar AL TABAA

Hôpital NOVO

PRINCIPAL_INVESTIGATORAuriane CHADELAT

Hôpital NOVO

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026