Early Postoperative Pain Following a Limb Amputation

Early Postoperative Pain and Functional Recovery Following a Limb Amputation: a Retrospective Observational Study.

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07393139

Acronym

Pain-Amp

Enrollment

150

Registered

2026-02-06

Start date

2026-01-09

Completion date

2026-04-01

Last updated

2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Amputation, Surgical, Pain Management, Rehabilitation

Keywords

Phantom limb pain, Amputation, Post-operative

Brief summary

The primary aim of this study is to characterize the trajectory of pain and functional recovery in the first post-operative period following a limb amputation. Secondarily, this study aims to conduct an exploratory analysis to evaluate potential associations between clinical, demographical and therapeutical variables and primary outcomes including pain intensity, pain control and functional recovery.

Detailed description

This retrospective observational study will be conducted at IRCCS Istituto Ortopedico Rizzoli. All patients who underwent an amputation at the IRCCS Istituto Ortopedico Rizzoli between January 1st 2023 and December 31st 2025 will be screened for eligibility based on predefined inclusion criteria. Once a patient is included into the study, all relevant data will be collected from their medical records.

Interventions

OTHERPain assessment

During hospitalization, patients were asked three times daily to rate their pain using the 11 point NRS scale. The highest rating of each day will be extracted from their medical records.

Study design

Observational model

COHORT

Time perspective

RETROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Patients ≥ 18 years of age * Patients who underwent an amputation to any limb, regardless of location or diagnosis

Exclusion criteria

* Patients with severe cognitive impairment or diagnosed with dementia * Patients deceased or in critical conditions within 48 hours of the intervention * Previous amputation to any limb * Admission to the hospital because of a stump revision

Design outcomes

Primary

Measure	Time frame	Description
Pain intensity	up to 30 days	Pain intensity was assessed using Numeric Rating Scale (NRS). The NRS is an 11 point scale from 0 to 10, with 0 indicating no pain and 10 representing the worst pain imaginable.

Secondary

Measure	Time frame	Description
Functional Recovery	up to 30 days	The number of days required for walking.

Countries

Italy

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026