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Preoperative and Postoperative Fasting and Delirium

The Relationship Between Preoperative and Postoperative Fasting Durations and Postoperative Delirium

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07391631
Acronym
FAST-POD
Enrollment
1000
Registered
2026-02-06
Start date
2026-03-01
Completion date
2027-12-01
Last updated
2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Postoperative Delirium Perioperative Fasting

Keywords

Postoperative Delirium, Preoperative Fasting, Postoperative Fasting, Surgical Patients, Observational Study, Multicenter Study

Brief summary

Postoperative delirium is a common and serious complication after surgery, especially in older patients, and is associated with prolonged hospital stay and worse recovery. Fasting before and after surgery is a routine part of perioperative care; however, prolonged fasting may negatively affect recovery and brain function. This prospective, observational, multicenter study aims to evaluate the relationship between preoperative and postoperative fasting durations and the development of postoperative delirium in adult patients undergoing elective or emergency surgery under general or regional anesthesia. Fasting times before and after surgery will be recorded. Patients will be assessed for postoperative delirium during the first three postoperative days using validated screening tools. No additional interventions will be applied, and all patients will receive standard perioperative care. The results of this study may help identify whether prolonged fasting is associated with a higher risk of postoperative delirium and may contribute to improving perioperative fasting practices and patient safety.

Detailed description

This is a prospective, observational, multicenter study designed to investigate the association between preoperative and postoperative fasting durations and the occurrence of postoperative delirium in adult surgical patients. Adult patients (≥18 years) undergoing elective or emergency surgery under general or regional anesthesia will be included. Patients with pre-existing delirium, advanced dementia, postoperative intensive care unit admission, or inability to complete delirium assessments will be excluded. Preoperative fasting duration will be defined as the time from the last oral intake to the induction of anesthesia. Postoperative fasting duration will be defined as the time from the end of surgery to the first oral intake. Fasting durations will be recorded for each participant. Postoperative delirium will be assessed using validated screening tools (Confusion Assessment Method or Nursing Delirium Screening Scale) twice daily during the first three postoperative days. Routine perioperative management will not be altered for study purposes, and no study-specific interventions will be applied. Demographic data, comorbidities, type of surgery, and perioperative clinical parameters will be collected as part of standard care. The primary objective is to evaluate the relationship between fasting durations and postoperative delirium. Secondary analyses will explore factors associated with delirium development.

Interventions

None listed

Sponsors

Akdeniz University
Lead SponsorOTHER
Turkish Society of Anesthesiology and Reanimation
CollaboratorOTHER

Study design

Observational model
COHORT
Time perspective
PROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No

Inclusion criteria

Adults aged 18 years or older Patients undergoing elective or emergency surgery under general or regional anesthesia Ability to communicate and cooperate with postoperative delirium assessments Expected postoperative hospital stay of at least 72 hours Provision of written informed consent \-

Exclusion criteria

Presence of preoperative delirium (positive CAM or Nu-DESC ≥2) Advanced dementia or severe cognitive impairment Planned postoperative intensive care unit admission Active alcohol or benzodiazepine withdrawal Inability to complete delirium assessments due to severe hearing, vision, or speech impairment Lack of postoperative follow-up availability Planned cardiac surgery \-

Design outcomes

Primary

MeasureTime frameDescription
Incidence of postoperative deliriumDuring the first 3 postoperative daysPostoperative delirium will be assessed using validated screening tools (Confusion Assessment Method or Nursing Delirium Screening Scale) during the first three postoperative days.

Secondary

MeasureTime frameDescription
Duration of postoperative deliriumDuring the first 3 postoperative daysThe duration of postoperative delirium will be recorded based on daily delirium assessments during the first three postoperative days.

Contacts

CONTACTemel gündüz, md
dregunduz@hotmail.com+902422496000

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026