Hemodialysis
Conditions
Keywords
Intradialytic exercise, Resistance exercise, Flexibility exercise, Quality of life, Clinical outcomes
Brief summary
This study examined whether different types of exercise performed during hemodialysis sessions affect patients' health and quality of life. Patients receiving regular hemodialysis were assigned to resistance exercise, flexibility exercise, or usual care during dialysis. Changes in health-related outcomes were evaluated before and after the exercise period.
Detailed description
This single-center pilot study was conducted to explore the effects of exercise performed during hemodialysis on patients' health. Adult patients undergoing maintenance hemodialysis participated in one of three groups: resistance exercise, flexibility exercise, or usual care without exercise. The exercise programs were carried out during routine dialysis sessions under supervision. Patients' clinical measurements and self-reported health outcomes were assessed at the start of the study and again after completion of the exercise period. The study was carried out between December 2020 and April 2021 following approval by the institutional ethics committee.
Interventions
BEHAVIORALResistance Exercise
A structured resistance exercise program performed during routine hemodialysis sessions under supervision.
BEHAVIORALFlexibility Exercise
A structured flexibility and stretching exercise program performed during routine hemodialysis sessions under supervision.
Sponsors
Dilek GİBYELİ GENEK
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
NONE
Masking description
Due to the nature of the exercise interventions, masking was not feasible.
Intervention model description
Participants were assigned to resistance exercise, flexibility exercise, or usual care groups and followed in parallel during the study period.
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Adults aged 18 years or older * Receiving maintenance hemodialysis for at least 3 months * Stable clinical condition * Ability to participate in exercise during hemodialysis sessions * Provided written informed consent
Exclusion criteria
* Acute illness or unstable cardiovascular disease * Severe musculoskeletal or neurological conditions limiting exercise * Recent hospitalization * Cognitive impairment preventing cooperation * Participation in another structured exercise program
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in dialysis adequacy assessed by Kt/V (urea) | From baseline to 12 weeks | Change in dialysis adequacy measured by single-pool Kt/V (urea). |
| Change in dialysis adequacy assessed by urea reduction ratio (URR) | From baseline to 12 weeks | Change in dialysis adequacy measured by urea reduction ratio (URR), expressed as a percentage |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Short Form-36 (SF-36) Health-Related Quality of Life score | From baseline to 12 weeks | Change in health-related quality of life assessed using the Short Form-36 Health Survey (SF-36), a validated 36-item questionnaire. SF-36 domain scores range from 0 to 100, with higher scores indicating better health-related quality of life. |
| Change in Beck Depression Inventory score | From baseline to 12 weeks | Change in depressive symptoms assessed using the Beck Depression Inventory (BDI). Scores range from 0 to 63, with higher scores indicating more severe depressive symptoms. |
| Change in body mass index (BMI) | From baseline to 12 weeks | Change in body mass index (BMI), calculated as weight in kilograms divided by height in meters squared (kg/m\^2). Higher BMI indicates greater body mass relative to height. |
| Change in fat tissue index (FTI) | From baseline to 12 weeks | Change in fat tissue index (FTI) assessed by bioelectrical impedance analysis (BIA), calculated from fat tissue mass (FTM) normalized to height squared (kg/m\^2). |
| Change in lean tissue index (LTI) | From baseline to 12 weeks | Change in lean tissue index (LTI) assessed by bioelectrical impedance analysis (BIA), calculated from lean tissue mass normalized to height squared (kg/m\^2). |
| Change in physical function assessed by the 6-minute walk test (6MWT) | From baseline to 12 weeks | Change in physical function assessed using the 6-minute walk test (6MWT), measured as the total distance walked in meters. |
Countries
Turkey (Türkiye)
Contacts
PRINCIPAL_INVESTIGATORDilek Gibyeli Genek, MD
Muğla Sıtkı Koçman University, Faculty of Medicine
Outcome results
None listed