Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic

Comparison of Pregabalin Versus Gabapentin as Pre-emptive Analgesic in Patients Undergoing Orthopedic Surgeries Under Spinal Anesthesia

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07389551

Enrollment

142

Registered

2026-02-05

Start date

2025-07-01

Completion date

2025-12-31

Last updated

2026-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Orthopedic Surgery

Brief summary

There are extensive gaps in the local data considering pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia. Therefore, the current study was planned with the objective of comparing pregabalin versus gabapentin as pre-emptive analgesics in patients undergoing orthopedic surgeries under spinal anesthesia.

Detailed description

Since postoperative pain in orthopedic surgery, whether neuropathic or nociceptive, presents a significant challenge for both surgeons and patients, knowing the more effective gabapentinoid as a pre-emptive analgesic would help clinicians to offer prolonged timing of first rescue analgesia and less opioid consumption.

Interventions

DRUGGabapentin

Patients were given a single oral dose of gabapentin 300 mg, with 30 ml of water, one hour prior to administration of spinal anesthesia.

DRUGPregabalin

Patients received pregabalin 150 mg as a single oral dose, with 30 ml of water, one hour prior to administration of spinal anesthesia.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Eligibility

Sex/Gender

ALL

Age

20 Years to 60 Years

Healthy volunteers

Inclusion criteria

* Either gender * Aged 20-60 years * Undergoing lower limb orthopedic surgeries under spinal anesthesia

Exclusion criteria

* Patients with a previous history of spine interventions, including surgery or injections (transforaminal, epidural, or facetal) for pain relief * Patients under any sort of pain modulation therapy, like transcutaneous electrical nerve stimulation * Patients had a long-term history of any analgesia use * Those with psychiatric disorders, alcohol/drug dependence, hepatic, renal, cardiac, or pulmonary abnormalities, * With a history of allergies to gabapentinoids

Design outcomes

Primary

Measure	Time frame	Description
Pain severity	24 hours	The severity of pain was analyzed on the visual analogue scale (VAS), with a lower score labelling the effectiveness of the treatment.
Analgesia duration	24 hours	The duration of analgesia was measured from awakening to the need of rescue analgesia, when a pain score was more than 3 on VAS.

Countries

Pakistan

Contacts

PRINCIPAL_INVESTIGATORMuhammad Usman

Bahawal Victoria Hospital/Quid-e-Azam Medical College, Bahawalpur

STUDY_DIRECTORAmbreen Khan, FCPS