Kidney Stones, Urine Specimen Collection
Conditions
Keywords
urine specimen collection, kidney stones
Brief summary
This is a single-center prospective cohort study to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry.
Detailed description
The primary objective of this study is to determine whether a two-week course of daily ACV supplementation significantly changes an individual's urine chemistry. The investigators will study this in healthy individuals and individuals with kidney stones.
Interventions
DIETARY_SUPPLEMENTApple Cider Vinegar
Goli Apple Cider Vinegar gummies
Sponsors
University of Chicago
Study design
Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
SUPPORTIVE_CARE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
Yes
Inclusion criteria
* Controls: Adults above the age of 18. * Kidney stone patients: Adults above the age of 18. * History of majority (\>50%) calcium oxalate kidney stones
Exclusion criteria
* Anyone with a history of calcium phosphate stones (\>50% calcium phosphate), uric acid stones, struvite stones, recent urinary tract instrumentation (\<30 days), or recurrent urinary tract infections. * Any individual who has had ACV outside of normal consumption in the prior month will be excluded. * Any individual who has a history of a negative reaction (increased acid reflux, allergy) to ACV will also be excluded. * Any individual with chronic kidney disease, underlying acid base disorder will also be excluded.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Measure changes in citrate in urine. | From Enrollment to 2 weeks | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. |
| Measure changes in Urine PH | From enrollment to 2 weeks | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. |
| Measure changes in calcium in urine. | from enrollment to 2 weeks | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. |
| Measure changes in calcium oxalate in urine | From Enrollment to 2 weeks | to evaluate the effect of short-term daily apple cider vinegar (ACV) supplementation on urine chemistry. |
Countries
United States
Contacts
CONTACTLuke Reynolds
PRINCIPAL_INVESTIGATORLuke Reynolds
The University of Chicago Medical Center
Outcome results
None listed