Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy

Impact of Serum Progesterone Levels on Embryo Transfer Day on Clinical Pregnancy in Frozen-thawed Embryo Transfer Cycles Using Hormone Replacement Therapy: a Prospective Observational Study

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07388797

Enrollment

370

Registered

2026-02-05

Start date

2026-01-20

Completion date

2028-12-31

Last updated

2026-05-11

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Reproductive Issues

Brief summary

Hypotheses: We hypothesize that serum progesterone levels on the day of embryo transfer in HRT-FET cycles are positively associated with clinical pregnancy rates. Aims: To evaluate the relationship between serum progesterone levels on embryo transfer day and clinical pregnancy outcomes in frozen-thawed embryo transfer cycles using hormone replacement therapy (HRT). Primary outcome: To compare the incidence of clinical pregnancy outcome in those infertility patients undergoing frozen embryo transfer with caterized Progesterone level on the day of embryo transfer Secondary outcomes: Biochemical pregnancy rate. Implantation rate. Early pregnancy loss rate. Ectopic pregnancy rate.

Interventions

None listed

Study design

Observational model

OTHER

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

FEMALE

Age

18 Years to 42 Years

Healthy volunteers

Inclusion criteria

* Patients undergoing FET cycles * Infertility patients aged \>18 years old and \< 42 years old * BMI \< 30 kg/m2 * Transfer of at least one good-quality embryo.

Exclusion criteria

* Severe endocrine disorders (e.g., thyroid dysfunction, premature ovarian failure). * Severe uterine factors without treatment (severe endometriosis, extensive or subendometrial fibroid, uterine adherent, endometrial polyps)

Design outcomes

Primary

Measure	Time frame	Description
Clinical pregnancy rate (CPR)	6 weeks of gestation and ultrasound scanning will be performed to confirm at least one gestational sac around 1 to 3 months after FET	Rate of clinical pregnancy outcome in subjects undergoing FET

Secondary

Measure	Time frame	Description
Biochemical pregnancy rate	Up to 12 weeks	Rate of biochemical pregnancy outcome in subjects undergoing FET
Implantation rate	Up to 12 weeks	Rate of implantation in subjects undergoing FET
Early pregnancy loss rate	Up to 12 weeks	Rate of early pregnancy loss in subjects undergoing FET
Ectopic pregnancy rate	Up to 12 weeks	Rate of Ectopic pregnancy in subjects undergoing FET

Countries

China

Outcome results