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Soluble and Osmotic Fibre (SOLOS) Diet for Constipation

The Soluble and Osmotic Fibre (SOLOS) Diet for Functional Bowel Disorders With Constipation

Status
Not yet recruiting
Phases
Unknown
Study type
Observational
Source
ClinicalTrials.gov
Registry ID
NCT07388589
Acronym
SOLOS
Enrollment
180
Registered
2026-02-05
Start date
2026-02-02
Completion date
2027-03-01
Last updated
2026-02-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Constipation, Constipation Chronic Idiopathic, Constipation - Functional, Constipation-predominant IBS (IBS-C), Constipation-predominant Irritable Bowel Syndrome, Constipation Predominant Irritable Bowel Syndrome, Constipation-predominant Irritable Bowel Syndrome (IBS-C), Constipation, Signs and Symptoms, Digestive, Dietary and Nutritional Therapies, Dietary Fiber, Dietary Fibers, Diet, Food and Nutrition, Diet Modification, Diet Therapy

Keywords

Constipation, Functional constipation, Constipation-predominant irritable bowel syndrome (IBS-C), Soluble fiber, osmotic sugar

Brief summary

This research aims to study the dual effectiveness of incorporating soluble fibre and osmotic carbohydrates (SOLOS), with or without restricting fructans and GOS, and present novel findings in managing GI symptoms in patients with functional bowel disorders with constipation. These findings may also support researchers and clinicians in shaping new dietary approaches in the management of general constipation symptoms.

Detailed description

Aims: This retrospective clinical audit study aims to evaluate the effectiveness of dietary advice promoting increased intake of soluble fibre and poorly absorbed (osmotic) carbohydrates, with or without restriction of fructans and galacto-oligosaccharides (GOS), on adult patients (18-70 years old) with functional bowel disorders with constipation from the UK by comparing to baseline scores for severity and frequency of gastrointestinal symptoms and stool output. Hypothesis: The dietary advice promoting increased intake of soluble fibre and osmotic sugars will produce a significant change from baseline in gastrointestinal symptoms and stool output in adult patients (18-70 years old) with functional bowel disorders with constipation from the UK. Methodology: The study population will include all patients who have consulted with the Principal Investigator, a specialist gastroenterology dietitian between January 2021 and December 2025. All patients who have met the inclusion criteria will then form the research sample. Eligible subjects' data and study variables will be extracted from patient letters and clinical management records without direct patient contact. These study variables include the frequency and severity of the patients' symptoms at their initial appointment and follow-up appointment if available. Anthropometric data such as height and weight will also be obtained. The compiled data will then be analysed by conducting statistical tests, specifically the paired t-test, which will produce descriptive statistics that will interpret the effectiveness of the SOLOS diet on patients with functional bowel disorders with constipation. Applications: To date, there has not been any study studying the dual effects of soluble fibre and osmotic carbohydrates consumption on alleviating constipation-related symptoms in patients with functional bowel disorders with constipation. Therefore, this research aims to present novel findings that can advance existing dietary management of functional bowel disorders with constipation. These results are expected to deepen understanding and research in food manufacturing and clinical nutrition.

Interventions

OTHERDiet

Dietary advice combining increased intake of dietary sources of soluble fibres and osmotic sugars in improving constipation symptoms.

Sponsors

Singapore Institute of Technology
Lead SponsorOTHER

Study design

Observational model
COHORT
Time perspective
RETROSPECTIVE

Eligibility

Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
No

Inclusion criteria

* Presented with symptoms of FC, IBS-C, or SIBO-C * Were aged 18 to 70 years old. (Research focus is on adult patients, excluding older adults and children) * Date of baseline (first) and follow-up appointments ranged from January 2021 to December 2025 * Did not attend follow-up appointments (Data would be treated as "intention to treat" and data points were carried forward for conservative analysis).

Exclusion criteria

* Had no history of constipation-related symptoms (Does not relate to research question's population or outcome) * Started treatment before January 2021 * Were not due for follow-up before the end of December 2025 * Symptom and stool data inadequately recorded

Design outcomes

Primary

MeasureTime frameDescription
Stool frequencyJanuary 2021 to December 2025Frequency of stool output per week
Stool formJanuary 2021 to December 2025Bristol Stool Form Scale
Gastrointestinal Symptom FrequencyJanuary 2021 to December 2025Frequency of gastrointestinal symptom in a week, recorded as number of days out of 7 the symptom occurred over the past week.
Gastrointestinal Symptom SeverityJanuary 2021 to December 2025Severity of symptoms in a week scored using Gastrointestinal Symptom Rating Scale (GSRS). Scores range from 0 (absent) to 3 (severe).

Countries

Singapore

Contacts

CONTACTBridgette J Wilson, Dr
bridgette.wilson@singaporetech.edu.sg+65 82629995
PRINCIPAL_INVESTIGATORBridgette J Wilson, Dr

Singapore Institute of Technology

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 7, 2026