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Polypharmacy on Healthy Aging in People Living With HIV Over the Age of 75

Describe and Evaluate the Impact of Polypharmacy on Healthy Aging in People Living With HIV Over the Age of 75 Who Are Being Treated at Nice University Hospital.

Status
Suspended
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07388394
Acronym
POLYVIH
Enrollment
136
Registered
2026-02-05
Start date
2026-01-28
Completion date
2027-05-31
Last updated
2026-09-02

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Virus-HIV

Brief summary

Since the advent of antiretroviral treatments, the life expectancy of people living with HIV (PLHIV) has increased significantly. In France, more than 30% of PLHIV are now over 50 years old. This population is exposed to high multimorbidity, leading to frequent polypharmacy, defined as the regular use of at least five medications. Polypharmacy also has a qualitative dimension, including potentially inappropriate prescriptions. It increases the risk of adverse effects and drug interactions and impairs quality of life. A coordinated geriatric approach is therefore essential to optimize care. Healthy aging, promoted by the WHO, aims to improve the lives of older people. In this context, a study will be conducted at the Nice University Hospital among PLHIV aged 75 and over. It will collect quantitative data, the results of which will enable us to consider, if necessary, adapting the care pathways of these patients whose needs are complex.

Interventions

OTHERinterview with advanced practice nurse

45 to 60 minutes of interview

Sponsors

Centre Hospitalier Universitaire de Nice
Lead SponsorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
OTHER
Masking
NONE

Eligibility

Sex/Gender
ALL
Age
75 Years to No maximum
Healthy volunteers
No

Inclusion criteria

* HIV-positive * Aged 75 or over * Affiliated with the social security system * Having expressed no objection to participating in the study

Exclusion criteria

* Refusal to participate * Known severe cognitive impairment preventing the interview from being conducted * Patient under guardianship or conservatorship

Design outcomes

Primary

MeasureTime frameDescription
Describe polypharmacy among people living with HIV aged 75 and older.15 monthsThe average number of medications taken

Secondary

MeasureTime frameDescription
Assess the most common comorbidities associated with polypharmacy in the population of PLHIV aged 7515 monthsNumber et type of comorbidities
Assess whether people taking multiple medications have a lower treatment adherence score than those taking fewer medications.15 monthsScore obtained on the Morisky MMAS-8 questionnaire
Assess the level of functional independence in this age group and link it to the existence of polypharmacy.15 monthsLawton and Brody IADL scale

Countries

France

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Sep 3, 2026