Total Laparoscopic vs Open Pancreaticoduodenectomy for the Treatment of Periampullary Adenocarcinomas

Status

Completed

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07388082

Enrollment

Registered

2026-02-04

Start date

2023-08-05

Completion date

2025-10-05

Last updated

2026-02-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Periampullary Carcinoma

Brief summary

Laparoscopic pancreaticoduodenectomy (LPD), a surgical option for nonpancreatic periampullary adenocarcinoma (NPPA), is a complex procedure that has become increasing popular. However, there is no consensus as to whether this technique should be performed routinely. Our aim was to evaluate the outcomes of LPD compared with open pancreaticoduodenectomy (OPD).

Interventions

PROCEDUREConventional open pancreaticoduedectomy

Fifteen patients in Group A had a traditional open pancreaticoduedectomy.

PROCEDURETotal laparoscopic pancreaticoduedectomy

Fifteen patients in Group A had a total laparoscopic pancreaticoduedectomy.

Study design

Allocation

RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

SINGLE (Subject)

Eligibility

Sex/Gender

ALL

Age

18 Years to 80 Years

Healthy volunteers

Inclusion criteria

* • Body mass index \<28.0 kg/m2. * Ampullary tumors, duodenal tumors restricted to the second part of the duodenum, or lower common bile duct tumors. * Carefully confirmed resectability of the tumors based on preoperative radiology conducted by experienced radiologists and surgeons.

Exclusion criteria

* • Patients with \>180 degrees superior mesenteric artery encasement * Any celiac abutment. * Unreconstructable superior mesenteric vein/portal occlusion" Aortic invasion or encasement. * A history of previous upper abdominal surgery. * Tumors extending to the uncinate. * Severe cardiorespiratory comorbidities.

Design outcomes

Primary

Measure	Time frame	Description
The incidence of pancreatic fistula after laparoscopic pancreaticoduodenectomy in comparison to open surgery	in 2 years between 2023 - 2025	Laparoscopic pancreaticoduodenectomy is a complex procedure that has become increasing popular. However, there is no consensus as to whether this technique should be performed routinely. Our aim was to evaluate the outcomes of Laparoscopic pancreaticoduodenectomy compared with open pancreaticoduodenectomy.

Countries

Egypt

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 24, 2026