L-PRF, Dental Implants, Osseointegration, Alveolar Bone Grafting
Conditions
Keywords
Dental implant, Platelet-rich fibrin, Alveolar ridge preservation, Dental implant stability, Tooth-socket preservation
Brief summary
Aim of study: The application of L-PRF membrane in post-extraction sockets outmatches the use of a) allograft covered with a collagen fleece b) allograft combined with L-PRF membrane c) natural healing, with reference to bone remodeling and regeneration of post-extraction sockets. Moreover, it will be examined whether the application of L-PRF membrane leads to faster bone maturation and creation of a favorable biological environment for earlier implant placement. Materials and methods: This study is taking place in Athens University Dental School, in Oral and Maxillofacial Surgery Clinic. All patients participating in the present study received thorough informed consent. All forty patients participating in this study, were subjected in at least one atraumatic and flapless extraction of a single rooted tooth in the maxilla or mandible. Then, the patients were randomly divided in four categories with regards to management of the socket: a) no intervention i.e. Natural healing b) application of L-PRF membrane in the socket c) application of allograft (Phoenix) covered with a collagen fleece d) application of allograft (Phoenix) covered with a L-PRF membrane. Interrupted sutures will be performed for the four extraction socket groups. Radiographic examination (localized CBCT) was obtained immediately before the extraction, as well as three months post-operatively (localized CBCT) in order to assess the changes in the alveolar ridge dimensions. The next stage of the study refers to the rehabilitation of the edentulous region. Before each patient was subjected to dental implant placement, a bone biopsy was obtained. Therefore, all the biopsy specimens obtained went through histological evaluation in order to assess qualitative and quantitative features.
Interventions
PROCEDUREAllograft and collagen membrane
The post-extraction sockets will be filled with allograft particles and collagen membrane.
PROCEDUREAllograft and L-PRF membrane
The post-extraction sockets will be filled with allograft particles and L-PRF membrane.
PROCEDUREL-PRF
The post-extraction sockets will be filled with L-PRF membrane.
Sponsors
National and Kapodistrian University of Athens
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Outcomes Assessor)
Eligibility
Sex/Gender
ALL
Age
18 Years to 85 Years
Healthy volunteers
Yes
Inclusion criteria
1. Single-rooted teeth needed to be extracted in the maxilla or mandible 2. Patient in good general health as documented by self-assessment 3. Patients must be committed to the study and sign the informed consent 4. Adults only as participants
Exclusion criteria
1. No systemic medical condition that could interfere with the surgical procedure or planned treatment. 2. Smokers \>20 cig/day 3. Current pregnancy or breast feeding 4. Radiotherapy or chemotherapy in head and neck area intravenous and oral bisphosphonates or anti-angiogenic drugs
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic assessment of the bone specimens | 3 months | Comparison of quantitative clinical alveolar ridge dimensions (in mm) between the four groups will be performed, 3 months after alveolar ridge preservation. Radiographic evaluation will take place and changes in horizontal dimension will be measured. The horizontal bone width of the ridge at the time of the extraction and after 3 months during the implant placement procedure will be measured in mm. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Radiographic assessment of the bone specimens | 3 months | Comparison of quantitative clinical alveolar ridge dimensions (in mm) between the four groups will be performed, 3 months after alveolar ridge preservation. Radiographic evaluation will take place and changes in vertical dimension will be measured. The vertical bone height of the ridge at the time of the extraction and after 3 months during the implant placement procedure will be measured in mm. |
| Histological assessment of the bone harvested from the post-extraction sockets | 3 months | Measure quantitative histologic characteristics of new bone formation between the four groups after 3 months of alveolar ridge preservation by quantifying the distribution in (%) of new vital bone formed at the healed socket site. |
Countries
Greece
Contacts
STUDY_CHAIRNadia Lygidakis, Associate Professor
National and Kapodistrian University of Athens
Outcome results
None listed