Crohn Disease
Conditions
Brief summary
From January 2020 to December 2024, Crohn's disease(CD) patients and gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University. The aim of this research is to explore the associations of B-cell activating factor(BAFF) gene polymorphisms with the risk and clinicopathological characteristics of CD.
Detailed description
From January 2020 to December 2024, a total of 310 CD patients and 514 gender- and age-matched normal controls were collected from the Department of Gastroenterology, the Second Affiliated Hospital of Wenzhou Medical University.The genotypes of BAFF were determined by multiplex polymerase chain reaction-ligase detection reaction technique. Unconditional logistic regression was employed to analyze the distribution of BAFF gene polymorphisms between CD group and normal control group, as well as their influences on the clinicopathological characteristics of CD patients.
Interventions
None listed
Sponsors
Second Affiliated Hospital of Wenzhou Medical University
Study design
Observational model
CASE_CONTROL
Time perspective
RETROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to 70 Years
Healthy volunteers
Yes
Inclusion criteria
* diagnosed CD based on comprehensive clinical, colonoscopy, histopathological, laboratory, and radiographic examination results
Exclusion criteria
* rheumatoid arthritis, systemic lupus erythematosus, intestinal tuberculosis, ischemic enteritis, radiation enteritis, tumors, etc
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| the genotypes of BAFF | Baseline | multiplex polymerase chain reaction-ligase detection reaction technique |
Countries
China
Outcome results
None listed