Bowel Endometriosis, Carcinogenesis, Colon Resection, Colorectal Carcinoma, Deep Endometriosis, Endometriosis, Endometriosis Pelvic, Endometriosis Rectum, Genetic Change, Infertility
Conditions
Brief summary
The goal of this study is to identify the molecular or genetic mechanisms that may predispose patients with bowel endometriosis to an increased risk of colorectal carcinoma. The study will include patients for whom surgical treatment of bowel endometriosis is clinically indicated. This research would represent a significant advancement in evaluating the necessity of surgical intervention in asymptomatic patients or those with mild symptoms. Furthermore, it would provide a broader insight into the systemic impact of endometriosis on other organ systems, ultimately improving risk assessment and preventive measures.
Interventions
None listed
Sponsors
University Medical Centre Ljubljana
Study design
Observational model
COHORT
Time perspective
CROSS_SECTIONAL
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Female patients aged 18 and over, treated at the Department of Reproduction for diagnosed deep endometriosis, including bowel endometriosis, for whom surgical treatment is indicated.
Exclusion criteria
* Patients with known inflammatory bowel disease (IBD), patients with a personal history of gynecological or gastrointestinal malignancy
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Comparison of gene expression in healthy and with endometriosis affected bowel. | 3 years |
Contacts
CONTACTRok Struna, MD
Outcome results
None listed