Cervical Cancer, Cervical Intraepithelial Neoplasm, Ovarian Cancer
Conditions
Keywords
3D power Doppler sonography, cervical vascularization and blood flow
Brief summary
This study will elucidate the role of 3D transvaginal ultrasound in assessing (1) cervical vascularity and blood flow in patients with cervical cancer and cervical intraepithelial neoplasm, and (2) tumor vascularity and blood flow in patients with ovarian cancer.
Detailed description
Patients and methods: Women with cervical cancer, cervical intraepithelial neoplasm, ovarian cancer, or the control will be invited to particilate in this study.Then, 3D power Doppler Ultrasound will be performed to capture (1) the cervical volume, vascularity and blood perfusion, and (2) ovarian tumor vascularity and blood perfusion. The sonographic data will be correlated to clinical and pathological data.
Interventions
DIAGNOSTIC_TESTDoppler ultrasound
3D doppler ultrasound to measure VI, FI, VFI.
Sponsors
Far Eastern Memorial Hospital
Study design
Observational model
CASE_CONTROL
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
FEMALE
Healthy volunteers
Yes
Inclusion criteria
* Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions, and the correlation between hemoperfusion and prognosis": 1. Adult women who have had a normal cervical smear within the past three years and have no other gynecological cancers (control group). 2. Adult women with cervical cancer or precancerous lesions. * Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer": 1. Adult women suspected of having ovarian cancer, fallopian tube cancer, or peritoneal cancer before surgery.
Exclusion criteria
* Regarding the topic "Hemoperfusion characteristics of cervical cancer and precancerous lesions of the cervix, and the correlation between hemoperfusion and prognosis": 1\. Patients who cannot cooperate with vaginal 3D ultrasound scans. * Regarding the topic "Correlation between hemoperfusion and prognosis of ovarian cancer": 1. Patients who cannot cooperate with vaginal or abdominal 3D ultrasound scans.
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Vascularization-flow index | 3 years | 1. Compare the vascularization-flow index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether vascularization-flow index is a predictor of progression-free survival in women with ovarian cancer |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Vascularization index | 3 years | 1\. Compare the vascularization index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether vascularization index is a predictor of progression-free survival in women with ovarian cancer |
| Flow index | 3 years | 1\. Compare the flow index values between cervical cancer, cervical intraepithelial neoplasia and the control group. 2. To assess whether flow index is a predictor of progression-free survival in women with ovarian cancer |
Countries
Taiwan
Outcome results
None listed