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Treatment Strategy for Complicated Pediatric Appendicitis Based on Laparoscopic Surgery

Treatment Strategy for Complicated Pediatric Appendicitis Based on Laparoscopic Surgery. Ten Years of Multicenter Cohort Study

Status
Completed
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07385261
Acronym
CALAP
Enrollment
765
Registered
2026-02-04
Start date
2015-01-01
Completion date
2026-01-01
Last updated
2026-02-04

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Appendix Diseases, Surgery

Keywords

laparoscopic surgery, complicated appendicitis

Brief summary

Observational retrospective study included 765 children with Operative management by laparoscopic appendectomy, conservative management for appendicular mass and drainage of abscess by IR should be tried first. Interval appendectomy is reserved only for patients with recurrent symptoms. the study collect the Diagnostic data ,intraoperative and post operative data to submit the strategies of laparoscopic management in limited resources setting.

Detailed description

Background and study aims: In children with complicated appendicitis significant morbidity exists with prolonged hospitalization and increased costs. The management strategy for complicated pediatric appendicitis differs depending on facility resources together with surgeon's experience. Various studies investigated the usefulness of laparoscopic than open surgery even in complicated appendicitis. However, the treatment strategy remains controversial, especially in appendicular mass as well as appendicular abscess. Methods: This observational study included 765 children with complicated appendicitis. over 10 years period. Patients' demographics, clinical criteria for different presentations of complicated appendicitis, diagnostic work up, plans of treatment based on laparoscopic management were reviewed and analyzed regarding different variables and postoperative outcomes.

Interventions

PROCEDURElaparoscopic appendectomy

Based on clinical findings, imaging studies and laboratory findings, after resuscitation, the decision of urgent surgery was according to the presentation Free peritoneal perforation (FPA) Perforated appendicitis with free peritoneal fluid were managed by urgent laparoscopic exploration Appendicular mass (AM) In patients presented by early mass formation lap exploration was carried out but trial of conservative management was planned for cases presented late with expected difficulty in lap dissection depending on surgical team and parental consultation, this accomplished by (nothing per mouth, I V fluid, I V antibiotic, temperature chart with U/S and biomarker follow up) Appendicular abscess (AAbs) Percutaneous drainage by availability IR team was the first choice however lap exploration and /or lap assisted extraperitoneal drainage was the second choice if IR failed or not available.

Sponsors

Mohammad Daboos
Lead SponsorOTHER
South Valley University
CollaboratorOTHER
Tanta University
CollaboratorOTHER

Study design

Allocation
NA
Intervention model
SINGLE_GROUP
Primary purpose
TREATMENT
Masking
NONE

Intervention model description

Single Group Assignment Pediatric patients aged less than 18 years, with Complicated appendicitis (with mass, appendicular abscess, and free collection) received surgical intervention with laparoscopy

Eligibility

Sex/Gender
ALL
Age
No minimum to 18 Years
Healthy volunteers
No

Inclusion criteria

* laparoscopic management of Complicated Appendicitis with mass formation * laparoscopic management of Complicated appendicitis with abscess formation: * laparoscopic management of Complicated appendicitis with free intraperitoneal collection

Exclusion criteria

* Open surgery cases * Patients received incomplete antibiotic therapy * Accidental discovery coexistent pathology that necessitates open surgery

Design outcomes

Primary

MeasureTime frameDescription
Primary outcomes4 yearspostoperative outcomes any alarming symptoms of intestinal obstruction developed (vomiting, fever, or severe abdominal pain, intraperitoneal collections

Countries

Egypt

Contacts

PRINCIPAL_INVESTIGATOR‪Mohammad Daboos‬, Dr

Department of pediatric surgery, faculty of medicine , Al-Azhar University

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026