Atheroma; Heart
Conditions
Keywords
Atheroma, Atherosclerosis, GARP, LRRC32
Brief summary
The leading cause of death is cardiovascular diseases in occidental countries. Of those, atherosclerosis is the major contributor to this burden being notably responsible for strokes and myocardial infarctions. The genesis of atherosclerosis is linked to both lipid accumulation and inflammation in the vascular wall of major arteries. One of the major pathways of inflammation is the TGF-beta axis which is at least partially regulated by the GARP protein. It has been investigated mostly in cancer biology but data in cardiovascular disease is lacking. Thus, the investigators aim to characterize the contribution of this protein by investigating its expression in circulating blood cells from patients with an acute or chronic coronary syndrom. The main cells expressing the GARP protein are the platelets and the T regulating cells which will be the main focus.
Interventions
BIOLOGICALArterial blood sample
An arterial blood sample will be obtained at the beginning of the coronary angiography by using the arterial sheat in place.
Sponsors
Université Catholique de Louvain
Fonds National de la Recherche Scientifique
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Older than 18 years * Able to give informed consent * Undergoing coronary angiography.
Exclusion criteria
* Patients younger than 18 years * Unable to give consent * Pregnancy * Dialysis
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Platelet GARP expression | Throughout the entire study, approximately during 2 years | The platelet GARP expression profile will be assessed and compared between arms using flow cytometry. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Inflammatory profile | Throughout the entire study, approximately during 2 years | The inflammatory cytokines (IL-1, IL-6, TNF,...) profile will be determined by multiplex and compared between arms. |
Countries
Belgium
Contacts
CONTACTLouis Charki, Medical Degree
PRINCIPAL_INVESTIGATORChristophe Beauloye, Medical Degree
Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Outcome results
None listed