Chronic Obstructive Pulmonary Disease, Immune Dysregulation, Immunotherapy Resistance, Lung Cancer (Diagnosis), Sarcoidosis
Conditions
Keywords
lung cancer, Non-Small Cell Lung Cancer, Sarcoidosis, Chronic Obstructive Pulmonary Disease, COPD, Immune Cells, Tumor Microenvironment, Immune Dysregulation, Immunotherapy, Immunotherapy Resistance, Immune Profiling, Myeloid Cells, Neutrophils, Dendritic Cells, Inflammation, Chronic Inflammation, Immune suppression, Emergency myelopoiesis
Brief summary
This study aims to better understand the role of immune system cells in lung diseases such as lung cancer, sarcoidosis, and chronic obstructive pulmonary disease (COPD). The investigators are studying how these immune cells can sometimes help the body defend itself, but in other cases may contribute to cancer growth or long-term lung inflammation. Although recent treatments like immunotherapy have improved cancer care, only a small proportion of patients currently benefit from these therapies. One goal of this research is to understand why some patients do not respond or develop resistance to treatment. The knowledge gained from this study may help researchers develop more effective and personalized treatments for people with lung diseases in the future.
Interventions
OTHERPeripheral Blood Collection for Immune Profiling
Participants provide biological samples for immune profiling and translational research. Samples include peripheral blood and, when available from routine clinical care, additional specimens such as tumor tissue or rlymph node, bone marrow. No experimental treatments are given. Collected samples are analyzed to characterize immune cell populations and their functional and molecular features, with the aim of studying immune mechanisms involved in lung cancer, sarcoidosis, and COPD, as well as factors associated with disease progression and treatment response. All medical care and treatment decisions remain independent of study participation.
Sponsors
Université Catholique de Louvain
Study design
Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
BASIC_SCIENCE
Masking
NONE
Intervention model description
This is a translational, non-interventional study evaluating immune cell populations in patients with lung cancer, sarcoidosis, and COPD. Participants receive only standard clinical care; no experimental treatments are given. Biological samples (primarily blood and when available, tumor, bone morrow samples collected for clinical reasons) and associated clinical data are analyzed to investigate immune mechanisms related to tumor progression, chronic lung inflammation, and response or resistance to therapy. The study is exploratory and comparative across diseases. All treatment decisions are made independently by the treating physicians and are not influenced by study participation.
Eligibility
Sex/Gender
ALL
Age
No minimum to 80 Years
Healthy volunteers
Yes
Inclusion criteria
* Diagnosis of lung cancer * Presence of precancerous lung lesions * Patients with a chronic inflammatory lung disease (sarcoidosis or chronic obstructive pulmonary disease \[COPD\]) prior to any treatment * Control group: individuals without known lung disease * Children and adolescents weighing ≥ 10 kg with genetically confirmed chronic granulomatous disease (CGD) * Adults scheduled to undergo orthopedic surgery during which a bone marrow sample will be collected
Exclusion criteria
* Systemic corticosteroid therapy \> 10 mg/day prednisone (or equivalent) * Acute infection at the time of inclusion * Refusal or inability to provide informed consent (or assent, when applicable) * Chronic inflammatory lung disease currently treated with immunosuppressive therapy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Progression free survival | Throughout the entire study, approximately during 7 years | median Progression free survival |
Countries
Belgium
Contacts
CONTACTFrank Aboubakar Nana, MD; PhD
CONTACTKim Henquin, Study nurse
STUDY_DIRECTORFrank Aboubakar Nana, MD; PhD
Cliniques universistaires saint Luc
Outcome results
None listed