Knee Osteoarthritis
Conditions
Keywords
Perineural Injection, Dextrose Injection, Local Anesthetic Injection, Pain, WOMAC, Observational Study
Brief summary
This prospective observational study aims to compare the clinical effectiveness of perineural 5% dextrose injections and perineural local anesthetic injections in patients with symptomatic knee osteoarthritis. Adult patients receiving routine perineural injection therapy will be followed for six months. Pain intensity and functional outcomes will be assessed at baseline and at 1, 3, and 6 months after treatment using validated clinical assessment tools.
Detailed description
Knee osteoarthritis is a common degenerative joint disease associated with chronic pain, functional limitation, and reduced quality of life. Various non-surgical treatment modalities have been used to manage symptoms; however, the effectiveness of these treatments may be limited due to the complex pain mechanisms involved in osteoarthritis. Perineural injection therapy has gained increasing attention as a minimally invasive treatment option targeting neurogenic inflammation around peripheral sensory nerves. Perineural 5% dextrose injection is thought to reduce pain by modulating neurogenic inflammation, while local anesthetic injections are commonly used in clinical practice for symptomatic relief. This study is designed as a prospective observational cohort study conducted in a routine clinical setting. Patients aged 40 to 65 years with symptomatic knee osteoarthritis who are treated with perineural injections as part of standard care will be included. The choice of injectate (perineural 5% dextrose or perineural local anesthetic) will be determined based on clinical considerations and patient preference; no randomization or protocol-driven assignment will be performed. Pain severity will be evaluated using the Visual Analog Scale (VAS). Functional status will be assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Additional clinical parameters, including knee range of motion measured by goniometry and quadriceps muscle strength assessed by manual muscle testing, will also be recorded. Assessments will be performed at baseline, and at 1, 3, and 6 months following treatment. Clinical outcomes of the two treatment groups will be compared to evaluate changes in pain and functional status over time. The findings of this study are expected to contribute real-world evidence regarding the clinical effectiveness of perineural 5% dextrose and local anesthetic injections in the management of symptomatic knee osteoarthritis.
Interventions
PROCEDUREPerineural 5% Dextrose Injection
Perineural injection of 5% dextrose solution administered around periarticular sensory nerves of the knee as part of routine clinical practice.
PROCEDUREPerineural Local Anesthetic Injection
Perineural injection of local anesthetic administered around periarticular sensory nerves of the knee as part of routine clinical practice.
Sponsors
Ankara Training and Research Hospital
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
40 Years to 65 Years
Healthy volunteers
No
Inclusion criteria
* Symptomatic knee osteoarthritis * Clinical/radiological diagnosis * Knee pain ≥ 3 months * Written informed consent
Exclusion criteria
* Prior knee surgery * Recent intra-articular injection * Inflammatory rheumatic disease * Severe systemic or neurological disease * Pregnancy or breastfeeding
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in Knee Pain Intensity (Visual Analog Scale [VAS]) | Baseline, 1 month, 3 months, and 6 months | Change in Knee Pain Intensity (Visual Analog Scale \[VAS\]) Change from baseline in knee pain intensity measured using the Visual Analog Scale (VAS), a 100-mm horizontal line anchored at 0 = no pain and 100 = worst imaginable pain; higher scores indicate worse pain. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in Functional Status (Western Ontario and McMaster Universities Osteoarthritis Index [WOMAC]) | Baseline, 1 month, 3 months, and 6 months | Change from baseline in WOMAC total score (and/or subscales: pain, stiffness, and physical function) assessing knee osteoarthritis-related symptoms. The WOMAC consists of 24 items with a total score ranging from 0 to 96; higher scores indicate worse symptoms and worse functional status. |
| Change in Knee Range of Motion | Baseline, 1 month, 3 months, and 6 months | Change in knee joint range of motion measured using goniometry. |
| Change in Quadriceps Muscle Strength | Baseline, 1 month, 3 months, and 6 months | Change in quadriceps muscle strength assessed by manual muscle testing. |
Countries
Turkey (Türkiye)
Contacts
CONTACTNadide Koca, M.D.
CONTACTHakan Genç, PROF. M.D.
Outcome results
None listed