geniculaR Artery eMBolization for Knee Osteoarthritis (RAMBO) Registry

Creation Of a Prospective Registry For Genicular Artery Embolization At The Joint & Vascular Institute

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07380906

Acronym

RAMBO

Enrollment

1200

Registered

2026-02-02

Start date

2025-07-16

Completion date

2030-07-01

Last updated

2026-06-12

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Knee Osteoarthristis

Keywords

knee osteoarthritis, embolization, GAE, Genicular Artery Embolization

Brief summary

The goal of this observational study (prospective registry) is to collect long-term real-world data on the effectiveness and safety of genicular artery embolization (GAE) for knee osteoarthritis in adults aged 18 years or older with symptomatic KOA that has not responded to medical therapy. The main questions it aims to answer are: 1. Does GAE lead to sustained improvement in pain (WOMAC, VAS) and quality-of-life scores over 12-36 months? 2. What patient or procedural factors are associated with better outcomes after GAE? Participants will: * Undergo GAE as part of their routine clinical care. * Complete clinical follow-up assessments at 1, 3, 6, 12, 18, 24, and 36 months after treatment, including symptom and quality-of-life questionnaires. * Have safety outcomes tracked according to Society of Interventional Radiology guidelines. There is no comparison group; results will be analyzed to identify predictors of success and inform best practices for patient selection and treatment.

Interventions

PROCEDUREGenicular Artery Embolization

Genicular Artery Embolization (GAE) is a minimally invasive, image-guided procedure in which embolic agents are delivered into hyperemic genicular arteries to reduce synovial inflammation and knee pain from osteoarthritis.

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Adults (≥18 years) with symptomatic KOA refractory to medical therapy, referred for GAE.

Exclusion criteria

* Pregnancy, coagulopathy, severe comorbidities, or inability to consent.

Design outcomes

Primary

Measure	Time frame	Description
Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)	5 years of enrollment/patient	The investigators will describe differences in pain response with Genicular Artery Embolization (GAE) compared to a sham procedure when treating medically refractory mild to moderate Knee Osteoarthritis (KOA) at 12 months as measured by the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) Pain subscale score. A higher score index a higher pain level while a lower score indicates lower pain levels. The score range is 0 to 96.

Countries

United States

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Jun 13, 2026