Lung Recruitment Assessed by 2D/3D-EIT and R/I Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation

Lung Recruitment Assessed by Two-Dimensional/Three-Dimensional Electrical Impedance Tomography and Recruitment-to-Inflation Ratio in Acute Respiratory Failure Patients With Mechanical Ventilation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07379242

Enrollment

Registered

2026-01-30

Start date

2025-09-01

Completion date

2026-09-30

Last updated

2026-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute Respiratory Failure (ARF)

Keywords

Acute respiratory failure, PEEP titration, 3D-EIT, 2D-EIT, Lung recruitability, R/I ratio

Brief summary

The purpose of this observational study is to assess the differences and consistency in evaluating lung recruitment potential between the recruitment-to-inflation ratio (R/I ratio) and three-dimensional electrical impedance tomography (3D-EIT) and two-dimensional EIT (2D-EIT) in mechanically ventilated patients with acute respiratory failure. The main questions it aims to answer is: Are the lung recruitment potentials predicted by 3D-EIT, 2D-EIT and the R/I ratio consistent? Participants will: Undergo a standardized PEEP titration protocol with synchronized EIT monitoring; Have R/I ratios measured at high and low PEEP levels.

Interventions

DIAGNOSTIC_TESTThe lung recruitment potential assessed and PEEP titration by ventilator and 2D/3D EIT

The patient will undergo a standardized PEEP titration procedure and determination of the Recruitment-to-Inflation ratio (R/I ratio), with concurrent monitoring by both 2D- and 3D- EIT.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* Mechanically ventilated patients under sedation and analgesia with no spontaneous breathing. * Oxygenation index \< 300 mmHg. * Patients who are clinically judged by the attending doctor to require the PEEP titration.

Exclusion criteria

* Aged under 18 years. * Pregnancy. * Contraindications for EIT examination (e.g. automatic implantable cardioverter defibrillator, implantable pumps, chest wounds limiting electrode belt placement, severe thoracic deformity, and others). * No informed consent obtained. * Hemodynamic instability with intolerance to high PEEP levels determined by the attending doctor. * High-risk populations with pneumothorax, mediastinal emphysema, and other such conditions determined by the attending doctor.

Design outcomes

Primary

Measure	Time frame	Description
Lung recruitment assessed by R/I ratio and 2D/3D-EIT （PEEP titration）	Within 24 hours post-enrollment	Lung recruitment potential can be predicted by the R/I ratio and the lung collapse rate calculated from 2D/3D-EIT.

Countries

China

Contacts

CONTACTHuaiwu He

tjmuhhw@126.com010-6915-2300

STUDY_CHAIRHuaiwu He

Peking Union Medical College Hospital

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026