Anti-Oxidative Stress, Skin Condition
Conditions
Keywords
Vitamin C supplement, Glutathione supplement
Brief summary
The objective of this study is to evaluate the effect of liquid vitamin C and glutathione supplements on human skin condition improvement and anti-oxidation.
Detailed description
This study is a single-center, placebo-controlled, double-blinded, parallel human trial designed to evaluate the skin beauty and anti-oxidant effect of liquid vitamin C and glutathione supplements. Healthy adult participants aged 18-65 years will be enrolled. Participants will be informed to consume test samples daily for 12 consecutive weeks. Skin measurement and self-assessment questionnaires will be conducted at baseline (before intake), after 4, 8 weeks, and 12 weeks of consumption. Fasting blood samples will be collected at baseline and after 12 weeks of consumption.
Interventions
DIETARY_SUPPLEMENTPlacebo sachet
consume 1 sachet of the test samples daily for 12 consecutive weeks
DIETARY_SUPPLEMENTVitamin C and Glutathione Liquid Sachet
consume 1 sachet of the test samples daily for 12 consecutive weeks
Sponsors
TCI Co., Ltd.
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 65 Years
Healthy volunteers
Yes
Inclusion criteria
* Healthy male or female adults, aged 18-65 years old; * Commitment not to use products having activity comparable with that of the product to be tested during the study period; * Free of any dermatological or systemic disorder that would interfere with results.
Exclusion criteria
* Subject with obvious skin surface damage; * Subject who had oral or topical medication which may affect skin condition within 1 month; * Individuals with known allergies to cosmetics, medications, or foods (especially those allergic to legumes/soy); * Pregnant or breastfeeding individuals; * Received facial laser therapy, chemical peeling in the past 2 months. * Individuals unwilling to allow publication or public disclosure of photographs taken as part of the study results
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin tone | Change from Baseline skin tone at 12 weeks | Chroma Meter MM500 was utilized to measure face skin tone. Units: Individual Typology Angle (ITA°) |
| The change of visible spots | Change from Baseline visible spots at 12 weeks | VISIA Complexion Analysis was utilized to measure visible spots on face. Units: the amount of detectable visible spots |
| The change of UV spots | Change from Baseline UV spots at 12 weeks | VISIA Complexion Analysis was utilized to measure UV spots on face. Units: the amount of detectable UV spots |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| The change of skin hydration | Change from Baseline skin hydration at 12 weeks | Corneometer® CM825 (CK, Germany) was utilized to measure skin surface hydation. Units: arbitrary Corneometer® units 0-120. |
| The change of skin redness | Change from Baseline skin redness at 12 weeks | Chroma Meter MM500 was utilized to measure face skin redness. Units: a\* value |
| The change of skin melanin index | Change from Baseline skin melanin index at 12 weeks | Mexameter® MX18 (CK, Germany) was utilized to measure face skin melanin level. Units: arbitrary units |
| The change of skin elasticity | Change from Baseline skin elasticity at 12 weeks | Skin elasticity (Softplus, Italy) was utilized to measure face skin elasticity. Units: arbitrary units |
| The change of brown spots | Change from Baseline brown spots at 12 weeks | VISIA Complexion Analysis was utilized to measure brown spots on face. Units: the amount of detectable brown spots |
| The change of wrinkles around the eyes | Change from Baseline wrinkles around the eyes at 12 weeks | VISIA Complexion Analysis was utilized to measure wrinkles around the eyes. Units: the amount of detectable wrinkles |
| The change of skin texture | Change from Baseline skin texture at 12 weeks | VISIA Complexion Analysis was utilized to measure skin texture. Units: arbitrary units |
| The change of skin collagen density | Change from Baseline skin collagen density at 12 weeks | DermaLab® Series SkinLab Combo was utilized to measure skin collagen density. Units: arbitrary units |
| The change of total antioxidation capacity (TAC) | Change from Baseline TAC at 12 weeks | A fasting blood sample will be collected for TAC testing. |
| The change of Superoxide Dismutase (SOD) | Change from Baseline SOD at 12 weeks | A fasting blood sample will be collected for SOD testing. |
| The change of Glutathione S-transferase-Red Blood Cells (GST-RBC) | Change from Baseline GST-RBC at 12 weeks | A fasting blood sample will be collected for GST-RBC testing. |
| The change of Malondialdehyde (MDA) | Change from Baseline MDA at 12 weeks | A fasting blood sample will be collected for MDA testing. |
Countries
Taiwan
Contacts
CONTACTChia-Hua Liang, Ph.D.
CONTACTPing Lin
PRINCIPAL_INVESTIGATORChia-Hua Liang, Ph.D.
Chia Nan University of Pharmacy ＆ Science
Outcome results
None listed