Cognitive Performance in Healthy Volunteers, Hemodynamic Measure
Conditions
Keywords
Theacrine, Hemodynamic measures, Cognitive Performance, Cortisol
Brief summary
This project measured physiological and cognitive variables to determine the effectiveness of Theacrine (TCR) as a stimulant at doses greater than those previously tested. The study will be the first TCR study to use doses relative to body weight and will investigate impacts on regular caffeine consumers. A secondary aim of the study is to determine the impact of acute TCR supplementation on salivary cortisol and sAA, two physiological measures of stress and sympathetic nervous system activation. The findings of the study will provide new insight into the effects of higher TCR dosages, contributing to the analysis of TCR as a caffeine alternative for individuals with hypertension, tachycardia, or healthy caffeine consumers wanting to avoid a stimulant with adverse or habitual effects
Interventions
DIETARY_SUPPLEMENTMaltodextrin (Placebo)
6 mg/kg Maltodextrin Placebo
DIETARY_SUPPLEMENTLow dose theacrine
3mg/kg theacrine
DIETARY_SUPPLEMENTMedium dose theacrine
6mg/kg theacrine
DIETARY_SUPPLEMENTHigh dose theacrine
9mg/kg theacrine
Sponsors
Titch Madzima
Study design
Allocation
RANDOMIZED
Intervention model
CROSSOVER
Primary purpose
OTHER
Masking
DOUBLE (Subject, Investigator)
Eligibility
Sex/Gender
ALL
Age
18 Years to 40 Years
Healthy volunteers
Yes
Inclusion criteria
\- habitual caffeine consumer (≥2 days/week)
Exclusion criteria
* existing heart disease or conditions (cardiovascular and/or heart disease, stroke, diabetes hypertension, tachycardia) * a smoker * allergy to caffeine or Theacrine * caffeine sensitivity (negative symptoms such as jitters after consuming low doses) * pregnant * on heart or blood pressure medication
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Change in systolic blood and diastolic blood pressure post consumption of theacrine | Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine | mmHg change in blood pressure measures |
| Change in heart rate post consumption of theacrine | Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine | beats per minute change in heart rate measure |
| Changes in executive function as a measure of cognitive performance using the Trail Making Test | Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine | Time to completion of the Trail Making Test as a measure of executive function |
| Changes in attention as a measure of cognitive performance using the Flanker Inhibitory Control and Attention task | Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine | Accuracy of congruent and incongruent trials as measures of attention |
| Changes in focus as a measure of cognitive performance using the Flanker Inhibitory Control and Attention task | Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine | Reaction time were recorded as measures of focus |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| Change in salivary cortisol and alpha-amylase post consumption of theacrine | Pre-consumption, then 60, 90, 120, 150, 180 minutes post-consumption of theacrine | µg/dL change in cortisol and alpha-amylase levels from baseline as non-invasive measures of physiological stress |
Countries
United States
Contacts
PRINCIPAL_INVESTIGATORTakudzwa A Madzima, PhD
Elon University
Outcome results
None listed