Cardiac Sympathetic Denervation in Patients With Refractory Arrhythmic Storm: a Single-center Case Series

Long-term Outcomes of Ultrasound-guided Percutaneous Bilateral Cardiac Sympathetic Denervation in Patients With Refractory Arrhythmic Storm: a Single-center Case Series

Status

Completed

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07375264

Enrollment

Registered

2026-01-29

Start date

2023-04-11

Completion date

2025-12-15

Last updated

2026-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Electrical Storm, Stellate Ganglion Block, Ventricular Arrhythmias

Keywords

Stellate ganglion block, Cardiac sympathetic denervation, Electrical storm, Ventricular arrhythmias

Brief summary

The objective of our study was to evaluate the effectiveness of stellate ganglion block (SGB) and of the bilateral cardiac sympathetic denervation (BCSD) in patients with electrical storm refractory to conventional treatment..

Detailed description

A prospective, single-center observational study was designed with the aim of evaluate the safety and short-term efficacy of SGB within the first 24 hours, as well as the long-term effectiveness of ultrasound-guided percutaneous BCSD at 12 months, in patients with refractory electrical storm.

Interventions

PROCEDURECardiac sympathetic denervation.

Patients underwent stellate ganglion block with 10 ml of levobupivacaine 0.25% and subsequently ultrasound-guided percutaneous bilateral cardiac sympathetic denervation , two neuroablative lesions were created using conventional radiofrequency treatment at 60°C, 20 V for 90 seconds.

Study design

Observational model

CASE_ONLY

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

18 Years to No maximum

Healthy volunteers

Inclusion criteria

* patients over 18 years of age. * arrhythmic storm refractory to conventional treatment.

Exclusion criteria

* patients younger than 18 years of age. * previous history of heart transplantation. * history of previous surgical cardiac sympathetic denervation. * patients with neck anatomy considered unsuitable for the procedure (including previous neck surgery, burns, the presence of extensive scars, or large goiters with significant displacement of adjacent structures). * contraindications to the interventional technique (such as infection at the puncture site, or refusal to provide consent).

Design outcomes

Primary

Measure	Time frame	Description
Arrhythmic burden.	The arrhythmic burden was assessed both in the early period (first 24 hours following SGB) and in the long term (during the 12 months following BCSD).	The arrhythmic burden was quantified by the number of sustained ventricular arrhythmias, antitachycardia pacing (ATP) therapies, and ICD (implantable cardioverter-defibrillator) shocks recorded during the follow-up period.

Countries

Spain

Contacts

PRINCIPAL_INVESTIGATORDaniel García Iglesias, MD.PhD

Central University Hospital of Asturias, 33001, Spain

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026