A Cohort Study on the Association Between the ANS Function and Acute GvHD

A Cohort Study on the Association Between the Autonomic Nervous System Function and Acute GvHD After Patients Receiving Allogeneic Hematopoietic Stem Cell Transplantation

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

ClinicalTrials.gov

Registry ID

NCT07374874

Enrollment

Registered

2026-01-29

Start date

2025-12-18

Completion date

2027-01-01

Last updated

2026-01-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Transplant-Related Disorder

Brief summary

This is a prospective observational study. The investigators plan to utilize this model as a tool for early classification and interrogate ANS function of transplant recipients.

Interventions

None listed

Study design

Observational model

COHORT

Time perspective

PROSPECTIVE

Eligibility

Sex/Gender

ALL

Age

16 Years to No maximum

Healthy volunteers

Inclusion criteria

1. Patients must be \> 16 years of age; 2. Patients receiving HLA-haploidentical transplants; 3. Patients have to sign an informed consent form before the start of the research procedure.

Exclusion criteria

1. Tandem transplantation or multiple transplantations; 2. Mental or other medical conditions that make the patients unable to comply with the research treatment and monitoring requirements; 3. Patients who are ineligible for the study due to other factors, or will bear great risk if participating in the study.

Design outcomes

Primary

Measure	Time frame	Description
Result of heart rate response to standing test	Within one month before the transplantation and during 17-25 days after the transplantation.	Autonomic nervous system functional tests including heart rate response to standing will be performed within one month before the transplantation and during 17-25 days after the transplantation.
Result of piloerection test	Within one month before the transplantation and during 17-25 days after the transplantation.	Autonomic nervous system functional tests including piloerection will be performed within one month before the transplantation and during 17-25 days after the transplantation.
Number of participants with abnormal dynamic electrocardiography readings	Within one month before the transplantation and during 17-25 days after the transplantation.	Dynamic electrocardiography will be performed within one month before the transplantation and during 17-25 days after the transplantation.

Secondary

Measure	Time frame
Incidence of severe acute GvHD after transplantation within 100 days and incidences of acute GvHD (any grade) in various target organs.	100 days after transplantation

Countries

China

Contacts

CONTACTYahui Feng

fengyahui@ihcams.ac.cn022-23608045

Outcome results