On Scene ECPR in Ostrava

The Effectiveness of ECPR on the Scene and in Hospital for Out-of-hospital Cardi-ac Arrest (OHCA) in the Moravian-Silesian Region.

Status

Recruiting

Phases

Unknown

Study type

Interventional

Source

ClinicalTrials.gov

Registry ID

NCT07374289

Enrollment

Registered

2026-01-28

Start date

2026-01-30

Completion date

2029-12-31

Last updated

2026-01-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Cardiac Arrest (CA), Cardiogenic Shock

Keywords

extracorporeal membrane oxygenation, out-of-hospital cardiac arrest, cardiac arrest, cardiogenic shock

Brief summary

On-scene extracorporeal pulmonary resuscitation (ECPR) for out-of-hospital cardiac arrest (OHCA) seems to speed up the start of extracorporeal membrane oxygenation (ECMO) and shorten low flow during cardiopulmonary resuscitation (CPR) in case of refractory cardiac arrest. The primary goal is to verify the benefit of on-scene ECPR in terms of shortening the collapse-to-ECMO interval. The secondary goal is to compare outcomes in the on-scene ECPR group with hospital cannulation.

Detailed description

ECPR is a life-saving method for a selected group of patients who are refractory to standard resuscitation procedures. With the appropriate use of ECPR, it is possible to achieve a significant improvement in survival with good neurological outcomes even in patients who would otherwise die. The ECMO Centre Ostrava has been providing ECPR for OHCA since 2022 with cannulation in the hospital after prior transport from the scene under continuous resuscitation. A good neurological outcome is achieved in approximately 29% of patients, even though the collapse-ECMO interval is around 75 minutes. Shortening this interval, which is associated with improved outcomes, is possible by using a mobile team that per-forms cannulation directly on scene. Mobile ECPR will be carried out in cooperation with the Ostrava University Hospital and the Moravian-Silesian Region Emergency Medical Service. The primary objective is to verify the benefit of on-scene ECPR in terms of shortening the collapse-ECMO interval. The secondary objective is to compare the outcome in the on-scene ECPR group with hospital cannulation.

Interventions

PROCEDUREPrehospital ECMO cannulation on scene of cardiac arrest

ECPR (Extracorporeal Cardiopulmonary Resuscitation) is a critical, advanced resuscitation technique using Veno-arterial Extracorporeal Membrane Oxygenation for patients in cardiac arrest where conventional CPR fails, functioning as a bridge to restore circulation and oxygenation by pumping and oxygenating blood outside the body before returning it.

PROCEDURETransfer with ongoing mechanical chest compression to hospital followed by hospital ECMO cannulation

Study design

Allocation

NON_RANDOMIZED

Intervention model

PARALLEL

Primary purpose

TREATMENT

Masking

NONE

Masking description

No masking will be used in the study.

Intervention model description

The study subjects will be enrolled in two parallel arms

Eligibility

Sex/Gender

ALL

Age

18 Years to 70 Years

Healthy volunteers

Inclusion criteria

* Presumed cardiac aetiology of the cardiac arrest * Witnessed collapse * Bystander CPR * Estimated age ≤ 70 years * Body weight ≥15 Kg

Exclusion criteria

* Known terminal malignant disease * Known terminal chronic disease

Design outcomes

Primary

Measure	Time frame	Description
Hospital survival	30 days after the cardiac arrest	Hospital survival will be assessed 30 days after the cardiac arrest
ICU stay	Through the ICU stay, on average 12 days	The length of the Intensive Care Unit (ICU) stay will be assessed in days.
Neurologic outcomes	30 days after the cardiac arrest	Neurologic outcomes will be assessed in patients using the Cerebral Performance Category (CPC) score. The CPC score is a 1-to-5 scale assessing neurological outcome, most commonly after cardiac arrest, where 1 is best (normal brain function) and 5 is worst (brain death).

Secondary

Measure	Time frame	Description
Collapse to ECMO interval	One hour	The interval from the collapse (cardiac arrest) to ECMO initiation will be measured in minutes.
Long-term outcome - Survival	6 months after the collapse	The long-term survival of patients will be assessed 6 months after the collapse.
Long-term outcome - Quality of Life	6 months after the collapse	Long-term quality of life will be assessed 6 months after the collapse using standardised tools (questionnaires).

Countries

Czechia

Contacts

CONTACTJiří Hynčica

jiri.hyncica@fno.cz+42059737

PRINCIPAL_INVESTIGATORFilip Burša, MD, PhD, EDEC

University Hospital Ostrava

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 4, 2026