Weaning Mechanical Ventilation
Conditions
Keywords
weaning, mechanical ventilation, ultrasound
Brief summary
Failure of liberation from mechanical ventilation increases days spent being mechanically ventilated, the length of stay and the morbidity of patients. Thus it is crucial that those patients who are ready to be liberated are accurately detected. In this study the investigators want to externally validate an index (the volume-velocity index, VVI) which in a preliminary study was found to predict with high accuracy the outcome of ventilator liberation. In this study, in patients who are deemed ready to undergo weaning by their treating physician the investigators will measure the excursion of the diaphragm, the principal respiratory muscle, the inspiratory time and the tidal volume and the volume breathed by the patient at each respiration in three phases: 1. during pressure support ventilation with 5/5, 2. during pressure support ventilation with 8/0, 3. during t-tube or pressure support ventilation with 0/0. All of these phases are ventilatory modalities widely used during weaning from mechanical ventilation. The investigators will evaluate whether VVI can predict accurately the weaning outcome.
Interventions
None listed
Sponsors
University of Thessaly
Study design
Observational model
COHORT
Time perspective
PROSPECTIVE
Eligibility
Sex/Gender
ALL
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
* Mechanically ventilated patients for more than 48h * First Spontaneous breathing trial * Deemed as ready to undergo weaning by the treating physician, according to published readiness criteria (DOI: 10.1183/09031936.00010206)
Exclusion criteria
* pregnant patients * preexisting diaphragmatic disease or injury * tracheostomy
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Weaning outcome | From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation. | Validate the predictive capability of VVI for weaning outcome |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| VVI for SBT or extubation | From the start of the spontaneous breathing trial to failure or success at 48 hours after exubation. | Comparison of the capability of VVI to predict SBT or extubation failure |
Countries
Greece
Contacts
CONTACTApostolos - Alkiviadis Menis, MD, PhD
CONTACTDemosthenes Makris
PRINCIPAL_INVESTIGATORApostolos - Alkiviadis Menis
General Hospital of Larissa
STUDY_DIRECTORDemosthenes Makris
University of Thessaly
Outcome results
None listed