Cervix, Dysplasia, Cervix Neoplasm
Conditions
Keywords
conization
Brief summary
Cervical transformation zone excision is commonly used in the diagnosis and treatment of cervical intraepithelial neoplasia. Thermal artifacts can negatively affect histopathological evaluation. This study compares three different modifications of conization performed using electrosurgery in terms of the degree of thermal artifacts.
Detailed description
Conization procedures performed using electrosurgical techniques, such as LEEP, NETZ, and SWETZ, are well described in the literature. Compared with cold knife conization, these methods offer several advantages, including the ability to be performed under local anesthesia, shorter procedure time, and lower cost. However, electrosurgical techniques may compromise histopathological evaluation of surgical specimens due to the presence of thermal artifacts, which can obscure tissue architecture and surgical margins. In our clinic, conization procedures are routinely performed using a hybrid technique that combines electrosurgery with cold knife conization. This study aims to compare three different modifications of this hybrid technique applied in our institution with respect to the degree of thermal artifact formation and the quality of surgical margin evaluation.
Interventions
PROCEDUREConization with Electrosurgery diffferent power settings
50 watts pure cut,50 watts blend mode
Sponsors
Saglik Bilimleri Universitesi
Study design
Allocation
RANDOMIZED
Intervention model
PARALLEL
Primary purpose
TREATMENT
Masking
SINGLE (Outcomes Assessor)
Eligibility
Sex/Gender
FEMALE
Age
18 Years to No maximum
Healthy volunteers
No
Inclusion criteria
Women aged ≥18 years Indication for LLETZ based on abnormal cervical cytology and/or biopsy Ability to provide written informed consent -
Exclusion criteria
Previous cervical excisional procedure Pregnancy Active cervical infection History of cervical cancer \-
Design outcomes
Primary
| Measure | Time frame | Description |
|---|---|---|
| Thermal Artefact | Within 7 days following the surgical procedure | Thermal artifact will be assessed by blinded gynecologic pathologists using a structured histopathological evaluation based on epithelial distortion, coagulative necrosis, and interference with margin interpretation. Thermal artifact severity will be graded as none, mild, moderate, or severe. |
Secondary
| Measure | Time frame | Description |
|---|---|---|
| TZ evaluation | postoperative 4th month | Transformation zone visibility will be evaluated during postoperative colposcopic examination and categorized as fully visible, partially visible, or not visible. |
Countries
Turkey (Türkiye)
Contacts
CONTACTSevda Bas
CONTACTAsena Torun
PRINCIPAL_INVESTIGATORSevda Bas
Universty of Health Science
Outcome results
None listed