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Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation

Evaluation of Low-Intensity Therapeutic Wavelength Nanotechnology Devices in Alveolar Preservation: A Clinical Trial

Status
Not yet recruiting
Phases
Unknown
Study type
Interventional
Source
ClinicalTrials.gov
Registry ID
NCT07371130
Acronym
APnanotecnolog
Enrollment
20
Registered
2026-01-27
Start date
2026-02-15
Completion date
2026-05-01
Last updated
2026-02-05

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Tooth Avulsion, Tooth Crown Fracture

Keywords

alveolar ridge preservation, alveolar preservation, bone loss, bone preservation

Brief summary

After tooth extraction, a progressive alveolar bone resorption is observed. Alveolar ridge preservation consists of placing a biomaterial within the extraction socket and covering it with a membrane. This procedure helps limit physiological bone resorption, making the soft and hard tissue profile of the edentulous site more prosthetically favorable.

Detailed description

After tooth extraction, a progressive remodeling process occurs that is often associated with significant alveolar bone resorption, particularly in sites with compromised bony walls. Alveolar ridge preservation is a surgical procedure aimed at minimizing this physiological resorption by placing grafting materials within the extraction socket and protecting them with a barrier membrane. In the present protocol, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration. In one study group, in addition to the surgical procedure, postoperative biostimulation using low-intensity photonic nanotechnology is applied. This adjunctive therapy is intended to enhance cellular metabolism, modulate inflammation, and accelerate both soft and hard tissue healing. The combined approach aims to preserve alveolar volume more effectively, improve the quality of regenerated tissues, and create a more favorable prosthetic environment for subsequent implant rehabilitation.

Interventions

PROCEDURESocket Preservation

After atraumatic tooth extraction, the socket is filled with a xenogeneic bone graft enriched with hyaluronic acid, which enhances biological activity by promoting angiogenesis, cell migration, and early wound healing. The grafted site is then covered with a dermal matrix membrane, providing mechanical protection, stabilization of the biomaterial, and guided tissue regeneration.

Sponsors

University of Bari Aldo Moro
Lead SponsorOTHER

Study design

Allocation
NON_RANDOMIZED
Intervention model
PARALLEL
Primary purpose
PREVENTION
Masking
SINGLE (Caregiver)

Eligibility

Sex/Gender
ALL
Age
21 Years to 80 Years
Healthy volunteers
Yes

Inclusion criteria

* Adults in good general health * Indication for tooth extraction in sites planned for delayed implant placement * Inability to place immediate post-extraction implants due to insufficient residual bone to ensure primary stability * Extraction sockets presenting absence of the buccal (vestibular) bone wall * Signed informed consent

Exclusion criteria

* Systemic conditions affecting bone healing * Uncontrolled periodontal disease * Smoking \>10 cigarettes/day * Pregnancy or lactation * Use of medications interfering with bone metabolism

Design outcomes

Primary

MeasureTime frameDescription
VAS1 day , 3 days , 7 days ,14 daysPostoperative pain assessment using the Visual Analog Scale (VAS) (1-10)
Analgesic consumption7 daysrecorded as the number of ibuprofen 400 mg tablets taken

Secondary

MeasureTime frameDescription
Histological Evaluation4- 6 month* Prior to implant placement, a CBCT scan will be performed to assess alveolar bone volume and morphology. * During implant site preparation, a bone core biopsy will be harvested using a trephine bur. * The bone sample will undergo histological and histomorphometric analysis to evaluate: * New bone formation * Residual graft material * Connective tissue percentage

Contacts

CONTACTGiuseppe D'Albis, Dr.
giuseppe.dalbis@uniba.it+393495103642
CONTACTDomenico Patarino, Dr.
domenico.patarino@gmail.com+393394359824
PRINCIPAL_INVESTIGATORGiuseppe D'Albis, Dr.

University of Bari Aldo Moro

PRINCIPAL_INVESTIGATORDomenico Patarino, Dr.

Private Practice

STUDY_DIRECTORSaverio Capodiferro, Prof. Dr.

University of Bari Aldo Moro

Outcome results

None listed

Source: ClinicalTrials.gov · Data processed: Feb 6, 2026